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Overview

Uniprot IDQ15431
Protein NameSynaptonemal complex protein 1
Gene NameSYCP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
170 EEGIQENKDLIKENN
738 ELGLYKSKEQEQSSL

Function

Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility

Protein Sequence

10 MEKQKPFALF 20 VPPRSSSSQV 30 SAVKPQTLGG 40 DSTFFKSFNK 50 CTEDDFEFPF 60 AKTNLSKNGE 70 NIDSDPALQK 80 VNFLPVLEQV 90 GNSDCHYQEG 100 LKDSDLENSE 110 GLSRVYSKLY 120 KEAEKIKKWK 130 VSTEAELRQK 140 ESKLQENRKI 150 IEAQRKAIQE 160 LQFGNEKVSL 170 KLEEGIQENK 180 DLIKENNATR 190 HLCNLLKETC 200 ARSAEKTKKY 210 EYEREETRQV 220 YMDLNNNIEK 230 MITAFEELRV 240 QAENSRLEMH 250 FKLKEDYEKI 260 QHLEQEYKKE 270 INDKEKQVSL 280 LLIQITEKEN 290 KMKDLTFLLE 300 ESRDKVNQLE 310 EKTKLQSENL 320 KQSIEKQHHL 330 TKELEDIKVS 340 LQRSVSTQKA 350 LEEDLQIATK 360 TICQLTEEKE 370 TQMEESNKAR 380 AAHSFVVTEF 390 ETTVCSLEEL 400 LRTEQQRLEK 410 NEDQLKILTM 420 ELQKKSSELE 430 EMTKLTNNKE 440 VELEELKKVL 450 GEKETLLYEN 460 KQFEKIAEEL 470 KGTEQELIGL 480 LQAREKEVHD 490 LEIQLTAITT 500 SEQYYSKEVK 510 DLKTELENEK 520 LKNTELTSHC 530 NKLSLENKEL 540 TQETSDMTLE 550 LKNQQEDINN 560 NKKQEERMLK 570 QIENLQETET 580 QLRNELEYVR 590 EELKQKRDEV 600 KCKLDKSEEN 610 CNNLRKQVEN 620 KNKYIEELQQ 630 ENKALKKKGT 640 AESKQLNVYE 650 IKVNKLELEL 660 ESAKQKFGEI 670 TDTYQKEIED 680 KKISEENLLE 690 EVEKAKVIAD 700 EAVKLQKEID 710 KRCQHKIAEM 720 VALMEKHKHQ 730 YDKIIEERDS 740 ELGLYKSKEQ 750 EQSSLRASLE 760 IELSNLKAEL 770 LSVKKQLEIE 780 REEKEKLKRE 790 AKENTATLKE 800 KKDKKTQTFL 810 LETPEIYWKL 820 DSKAVPSQTV 830 SRNFTSVDHG 840 ISKDKRDYLW 850 TSAKNTLSTP 860 LPKAYTVKTP 870 TKPKLQQREN 880 LNIPIEESKK 890 KRKMAFEFDI 900 NSDSSETTDL 910 LSMVSEEETL 920 KTLYRNNNPP 930 ASHLCVKTPK 940 KAPSSLTTPG 950 STLKFGAIRK 960 MREDRWAVIA 970 KMDRKKKLKE AEKLFV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030849 autosome
Cellular Component GO:0000801 central element
Cellular Component GO:0005694 chromosome
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0001673 male germ cell nucleus
Cellular Component GO:0000795 synaptonemal complex
Cellular Component GO:0000802 transverse filament
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003690 double-stranded DNA binding
Biological Process GO:0051301 cell division
Biological Process GO:0051026 chiasma assembly
Biological Process GO:0007129 homologous chromosome pairing at meiosis
Biological Process GO:0035825 homologous recombination
Biological Process GO:0051878 lateral element assembly
Biological Process GO:0000711 meiotic DNA repair synthesis
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0007131 reciprocal meiotic recombination
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0007130 synaptonemal complex assembly

Reference

[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.