Search Results
Overview
| Uniprot ID | Q15464 |
|---|---|
| Protein Name | SH2 domain-containing adapter protein B |
| Gene Name | SHB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 223 | GGKKLLNKCAASAAE |
Function
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells
Protein Sequence
10
MAKWLNKYFS
20
LGNSKTKSPP
30
QPPRPDYREQ
40
RRRGERPSQP
50
PQAVPQASSA
60
ASASCGPATA
70
SCFSASSGSL
80
PDDSGSTSDL
90
IRAYRAQKER
100
DFEDPYNGPG
110
SSLRKLRAMC
120
RLDYCGGSGE
130
PGGVQRAFSA
140
SSASGAAGCC
150
CASSGAGAAA
160
SSSSSSGSPH
170
LYRSSSERRP
180
ATPAEVRYIS
190
PKHRLIKVES
200
AAGGGAGDPL
210
GGACAGGRTW
220
SPTACGGKKL
230
LNKCAASAAE
240
ESGAGKKDKV
250
TIADDYSDPF
260
DAKNDLKSKA
270
GKGESAGYME
280
PYEAQRIMTE
290
FQRQESVRSQ
300
HKGIQLYDTP
310
YEPEGQSVDS
320
DSESTVSPRL
330
RESKLPQDDD
340
RPADEYDQPW
350
EWNRVTIPAL
360
AAQFNGNEKR
370
QSSPSPSRDR
380
RRQLRAPGGG
390
FKPIKHGSPE
400
FCGILGERVD
410
PAVPLEKQIW
420
YHGAISRGDA
430
ENLLRLCKEC
440
SYLVRNSQTS
450
KHDYSLSLRS
460
NQGFMHMKLA
470
KTKEKYVLGQ
480
NSPPFDSVPE
490
VIHYYTTRKL
500
PIKGAEHLSL
LYPVAVRTL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0030159 | signaling receptor complex adaptor activity |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0007165 | signal transduction |
Reference
PMID: N/A