Search Results

Overview

Uniprot IDQ15493
Protein NameRegucalcin
Gene NameRGN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
106 NNRFNDGKVDPAGRY
144 LFPDHHVKKYFDQVD
198 RSVYKLEKEEQIPDG
233 RLDPVTGKRLQTVKL
244 TVKLPVDKTTSCCFG
97 LATVDNDKKNNRFND

Function

Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity)

Protein Sequence

10 MSSIKIECVL 20 PENCRCGESP 30 VWEEVSNSLL 40 FVDIPAKKVC 50 RWDSFTKQVQ 60 RVTMDAPVSS 70 VALRQSGGYV 80 ATIGTKFCAL 90 NWKEQSAVVL 100 ATVDNDKKNN 110 RFNDGKVDPA 120 GRYFAGTMAE 130 ETAPAVLERH 140 QGALYSLFPD 150 HHVKKYFDQV 160 DISNGLDWSL 170 DHKIFYYIDS 180 LSYSVDAFDY 190 DLQTGQISNR 200 RSVYKLEKEE 210 QIPDGMCIDA 220 EGKLWVACYN 230 GGRVIRLDPV 240 TGKRLQTVKL 250 PVDKTTSCCF 260 GGKNYSEMYV 270 TCARDGMDPE 280 GLLRQPEAGG 290 IFKITGLGVK GIAPYSYAG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030234 enzyme regulator activity
Molecular Function GO:0004341 gluconolactonase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0019853 L-ascorbic acid biosynthetic process
Biological Process GO:0032781 positive regulation of ATP-dependent activity
Biological Process GO:0050848 regulation of calcium-mediated signaling

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.