Search Results
Overview
| Uniprot ID | Q15506 |
|---|---|
| Protein Name | Sperm surface protein Sp17 |
| Gene Name | SPA17 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 63 | DPAEWGSKVEDRFYN |
Function
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)
Protein Sequence
10
MSIPFSNTHY
20
RIPQGFGNLL
30
EGLTREILRE
40
QPDNIPAFAA
50
AYFESLLEKR
60
EKTNFDPAEW
70
GSKVEDRFYN
80
NHAFEEQEPP
90
EKSDPKQEES
100
QISGKEEETS
110
VTILDSSEED
120
KEKEEVAAVK
130
IQAAFRGHIA
140
REEAKKMKTN
150
SLQNEEKEEN
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0031514 | motile cilium |
| Cellular Component | GO:0035686 | sperm fibrous sheath |
| Cellular Component | GO:0097228 | sperm principal piece |
| Molecular Function | GO:0005516 | calmodulin binding |
| Biological Process | GO:0007339 | binding of sperm to zona pellucida |
| Biological Process | GO:0003351 | epithelial cilium movement involved in extracellular fluid movement |
| Biological Process | GO:0007338 | single fertilization |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.