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Overview

Uniprot IDQ15532
Protein NameProtein SSXT
Gene NameSS18
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
13 AAPRQRGKGEITPAA

Function

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058)

Protein Sequence

10 MSVAFAAPRQ 20 RGKGEITPAA 30 IQKMLDDNNH 40 LIQCIMDSQN 50 KGKTSECSQY 60 QQMLHTNLVY 70 LATIADSNQN 80 MQSLLPAPPT 90 QNMPMGPGGM 100 NQSGPPPPPR 110 SHNMPSDGMV 120 GGGPPAPHMQ 130 NQMNGQMPGP 140 NHMPMQGPGP 150 NQLNMTNSSM 160 NMPSSSHGSM 170 GGYNHSVPSS 180 QSMPVQNQMT 190 MSQGQPMGNY 200 GPRPNMSMQP 210 NQGPMMHQQP 220 PSQQYNMPQG 230 GGQHYQGQQP 240 PMGMMGQVNQ 250 GNHMMGQRQI 260 PPYRPPQQGP 270 PQQYSGQEDY 280 YGDQYSHGGQ 290 GPPEGMNQQY 300 YPDGHNDYGY 310 QQPSYPEQGY 320 DRPYEDSSQH 330 YYEGGNSQYG 340 QQQDAYQGPP 350 PQQGYPPQQQ 360 QYPGQQGYPG 370 QQQGYGPSQG 380 GPGPQYPNYP 390 QGQGQQYGGY 400 RPTQPGPPQP 410 PQQRPYGYDQ GQYGNYQQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0071564 npBAF complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016514 SWI/SNF complex
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045596 negative regulation of cell differentiation
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:1902459 positive regulation of stem cell population maintenance
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.