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Overview

Uniprot IDQ15555
Protein NameMicrotubule-associated protein RP/EB family member 2
Gene NameMAPRE2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
132 FKRMNVDKVIPVEKL
194 QIFNLPKKSHHANSP
235 SSSGSASKSDKDLET
238 GSASKSDKDLETQVI
263 LALEGVEKERDFYFG
271 ERDFYFGKLREIELL

Function

Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684)

Protein Sequence

10 MPGPTQTLSP 20 NGENNNDIIQ 30 DNNGTIIPFR 40 KHTVRGERSY 50 SWGMAVNVYS 60 TSITQETMSR 70 HDIIAWVNDI 80 VSLNYTKVEQ 90 LCSGAAYCQF 100 MDMLFPGCIS 110 LKKVKFQAKL 120 EHEYIHNFKL 130 LQASFKRMNV 140 DKVIPVEKLV 150 KGRFQDNLDF 160 IQWFKKFYDA 170 NYDGKEYDPV 180 EARQGQDAIP 190 PPDPGEQIFN 200 LPKKSHHANS 210 PTAGAAKSSP 220 AAKPGSTPSR 230 PSSAKRASSS 240 GSASKSDKDL 250 ETQVIQLNEQ 260 VHSLKLALEG 270 VEKERDFYFG 280 KLREIELLCQ 290 EHGQENDDLV 300 QRLMDILYAS 310 EEHEGHTEEP 320 EAEEQAHEQQ PPQQEEY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005881 cytoplasmic microtubule
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0035371 microtubule plus-end
Cellular Component GO:0051233 spindle midzone
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0051010 microtubule plus-end binding
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0051301 cell division
Biological Process GO:0032014 positive regulation of ARF protein signal transduction
Biological Process GO:0120183 positive regulation of focal adhesion disassembly
Biological Process GO:0051549 positive regulation of keratinocyte migration
Biological Process GO:0035372 protein localization to microtubule
Biological Process GO:0031110 regulation of microtubule polymerization or depolymerization
Biological Process GO:0051225 spindle assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.