Search Results
Overview
| Uniprot ID | Q15560 |
|---|---|
| Protein Name | Transcription elongation factor A protein 2 |
| Gene Name | TCEA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 86 | LLDASDAKARERGRG |
Function
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus
Protein Sequence
10
MMGKEEEIAR
20
IARRLDKMVT
30
KKSAEGAMDL
40
LRELKAMPIT
50
LHLLQSTRVG
60
MSVNALRKQS
70
SDEEVIALAK
80
SLIKSWKKLL
90
DASDAKARER
100
GRGMPLPTSS
110
RDASEAPDPS
120
RKRPELPRAP
130
STPRITTFPP
140
VPVTCDAVRN
150
KCREMLTAAL
160
QTDHDHVAIG
170
ADCERLSAQI
180
EECIFRDVGN
190
TDMKYKNRVR
200
SRISNLKDAK
210
NPDLRRNVLC
220
GAITPQQIAV
230
MTSEEMASDE
240
LKEIRKAMTK
250
EAIREHQMAR
260
TGGTQTDLFT
270
CGKCRKKNCT
280
YTQVQTRSSD
290
EPMTTFVVCN
ECGNRWKFC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0008023 | transcription elongation factor complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003711 | transcription elongation factor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006354 | DNA-templated transcription elongation |
| Biological Process | GO:0032784 | regulation of DNA-templated transcription elongation |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.