Search Results
Overview
| Uniprot ID | Q15573 |
|---|---|
| Protein Name | TATA box-binding protein-associated factor RNA polymerase I subunit A |
| Gene Name | TAF1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 354 | TAWKYLAKYLKNILM |
Function
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits
Protein Sequence
10
MSDFSEELKG
20
PVTDDEEVET
30
SVLSGAGMHF
40
PWLQTYVETV
50
AIGGKRRKDF
60
AQTTSACLSF
70
IQEALLKHQW
80
QQAAEYMYSY
90
FQTLEDSDSY
100
KRQAAPEIIW
110
KLGSEILFYH
120
PKSNMESFNT
130
FANRMKNIGV
140
MNYLKISLQH
150
ALYLLHHGML
160
KDAKRNLSEA
170
ETWRHGENTS
180
SREILINLIQ
190
AYKGLLQYYT
200
WSEKKMELSK
210
LDKDDYAYNA
220
VAQDVFNHSW
230
KTSANISALI
240
KIPGVWDPFV
250
KSYVEMLEFY
260
GDRDGAQEVL
270
TNYAYDEKFP
280
SNPNAHIYLY
290
NFLKRQKAPR
300
SKLISVLKIL
310
YQIVPSHKLM
320
LEFHTLLRKS
330
EKEEHRKLGL
340
EVLFGVLDFA
350
GCTKNITAWK
360
YLAKYLKNIL
370
MGNHLAWVQE
380
EWNSRKNWWP
390
GFHFSYFWAK
400
SDWKEDTALA
410
CEKAFVAGLL
420
LGKGCRYFRY
430
ILKQDHQILG
440
KKIKRMKRSV
450
KKYSIVNPRL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005668 | RNA polymerase transcription factor SL1 complex |
| Molecular Function | GO:0003677 | DNA binding |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0006360 | transcription by RNA polymerase I |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.