Search Results
Overview
| Uniprot ID | Q15582 |
|---|---|
| Protein Name | Transforming growth factor-beta-induced protein ig-h3 |
| Gene Name | TGFBI |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 219 | VNCARLLKADHHATN |
| 441 | LLRNHIIKDQLASKY |
| 447 | IKDQLASKYLYHGQT |
| 461 | TLETLGGKKLRVFVY |
| 484 | SCIAAHDKRGRYGTL |
| 510 | GTVMDVLKGDNRFSM |
| 53 | PNVCAVQKVIGTNRK |
| 563 | SRLLGDAKELANILK |
| 590 | IGALVRLKSLQGDKL |
| 596 | LKSLQGDKLEVSLKN |
| 60 | KVIGTNRKYFTNCKQ |
| 602 | DKLEVSLKNNVVSVN |
| 66 | RKYFTNCKQWYQRKI |
| 76 | YQRKICGKSTVISYE |
Function
Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity)
Protein Sequence
10
MALFVRLLAL
20
ALALALGPAA
30
TLAGPAKSPY
40
QLVLQHSRLR
50
GRQHGPNVCA
60
VQKVIGTNRK
70
YFTNCKQWYQ
80
RKICGKSTVI
90
SYECCPGYEK
100
VPGEKGCPAA
110
LPLSNLYETL
120
GVVGSTTTQL
130
YTDRTEKLRP
140
EMEGPGSFTI
150
FAPSNEAWAS
160
LPAEVLDSLV
170
SNVNIELLNA
180
LRYHMVGRRV
190
LTDELKHGMT
200
LTSMYQNSNI
210
QIHHYPNGIV
220
TVNCARLLKA
230
DHHATNGVVH
240
LIDKVISTIT
250
NNIQQIIEIE
260
DTFETLRAAV
270
AASGLNTMLE
280
GNGQYTLLAP
290
TNEAFEKIPS
300
ETLNRILGDP
310
EALRDLLNNH
320
ILKSAMCAEA
330
IVAGLSVETL
340
EGTTLEVGCS
350
GDMLTINGKA
360
IISNKDILAT
370
NGVIHYIDEL
380
LIPDSAKTLF
390
ELAAESDVST
400
AIDLFRQAGL
410
GNHLSGSERL
420
TLLAPLNSVF
430
KDGTPPIDAH
440
TRNLLRNHII
450
KDQLASKYLY
460
HGQTLETLGG
470
KKLRVFVYRN
480
SLCIENSCIA
490
AHDKRGRYGT
500
LFTMDRVLTP
510
PMGTVMDVLK
520
GDNRFSMLVA
530
AIQSAGLTET
540
LNREGVYTVF
550
APTNEAFRAL
560
PPRERSRLLG
570
DAKELANILK
580
YHIGDEILVS
590
GGIGALVRLK
600
SLQGDKLEVS
610
LKNNVVSVNK
620
EPVAEPDIMA
630
TNGVVHVITN
640
VLQPPANRPQ
650
ERGDELADSA
660
LEIFKQASAF
670
SRASQRSVRL
680
APVYQKLLER
MKH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0071953 | elastic fiber |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0001527 | microfibril |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0050839 | cell adhesion molecule binding |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0050840 | extracellular matrix binding |
| Molecular Function | GO:0005201 | extracellular matrix structural constituent |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005178 | integrin binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0002062 | chondrocyte differentiation |
| Biological Process | GO:0030198 | extracellular matrix organization |
| Biological Process | GO:0007162 | negative regulation of cell adhesion |
| Biological Process | GO:0007601 | visual perception |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.