Search Results

Overview

Uniprot IDQ15596
Protein NameNuclear receptor coactivator 2
Gene NameNCOA2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
640 HDSKGQTKLLQLLTT
780 TDPASNTKLIAMKTE

Function

Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:23508108). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity)

Protein Sequence

10 MSGMGENTSD 20 PSRAETRKRK 30 ECPDQLGPSP 40 KRNTEKRNRE 50 QENKYIEELA 60 ELIFANFNDI 70 DNFNFKPDKC 80 AILKETVKQI 90 RQIKEQEKAA 100 AANIDEVQKS 110 DVSSTGQGVI 120 DKDALGPMML 130 EALDGFFFVV 140 NLEGNVVFVS 150 ENVTQYLRYN 160 QEELMNKSVY 170 SILHVGDHTE 180 FVKNLLPKSI 190 VNGGSWSGEP 200 PRRNSHTFNC 210 RMLVKPLPDS 220 EEEGHDNQEA 230 HQKYETMQCF 240 AVSQPKSIKE 250 EGEDLQSCLI 260 CVARRVPMKE 270 RPVLPSSESF 280 TTRQDLQGKI 290 TSLDTSTMRA 300 AMKPGWEDLV 310 RRCIQKFHAQ 320 HEGESVSYAK 330 RHHHEVLRQG 340 LAFSQIYRFS 350 LSDGTLVAAQ 360 TKSKLIRSQT 370 TNEPQLVISL 380 HMLHREQNVC 390 VMNPDLTGQT 400 MGKPLNPISS 410 NSPAHQALCS 420 GNPGQDMTLS 430 SNINFPINGP 440 KEQMGMPMGR 450 FGGSGGMNHV 460 SGMQATTPQG 470 SNYALKMNSP 480 SQSSPGMNPG 490 QPTSMLSPRH 500 RMSPGVAGSP 510 RIPPSQFSPA 520 GSLHSPVGVC 530 SSTGNSHSYT 540 NSSLNALQAL 550 SEGHGVSLGS 560 SLASPDLKMG 570 NLQNSPVNMN 580 PPPLSKMGSL 590 DSKDCFGLYG 600 EPSEGTTGQA 610 ESSCHPGEQK 620 ETNDPNLPPA 630 VSSERADGQS 640 RLHDSKGQTK 650 LLQLLTTKSD 660 QMEPSPLASS 670 LSDTNKDSTG 680 SLPGSGSTHG 690 TSLKEKHKIL 700 HRLLQDSSSP 710 VDLAKLTAEA 720 TGKDLSQESS 730 STAPGSEVTI 740 KQEPVSPKKK 750 ENALLRYLLD 760 KDDTKDIGLP 770 EITPKLERLD 780 SKTDPASNTK 790 LIAMKTEKEE 800 MSFEPGDQPG 810 SELDNLEEIL 820 DDLQNSQLPQ 830 LFPDTRPGAP 840 AGSVDKQAII 850 NDLMQLTAEN 860 SPVTPVGAQK 870 TALRISQSTF 880 NNPRPGQLGR 890 LLPNQNLPLD 900 ITLQSPTGAG 910 PFPPIRNSSP 920 YSVIPQPGMM 930 GNQGMIGNQG 940 NLGNSSTGMI 950 GNSASRPTMP 960 SGEWAPQSSA 970 VRVTCAATTS 980 AMNRPVQGGM 990 IRNPAASIPM 1000 RPSSQPGQRQ 1010 TLQSQVMNIG 1020 PSELEMNMGG 1030 PQYSQQQAPP 1040 NQTAPWPESI 1050 LPIDQASFAS 1060 QNRQPFGSSP 1070 DDLLCPHPAA 1080 ESPSDEGALL 1090 DQLYLALRNF 1100 DGLEEIDRAL 1110 GIPELVSQSQ 1120 AVDPEQFSSQ 1130 DSNIMLEQKA 1140 PVFPQQYASQ 1150 AQMAQGSYSP 1160 MQDPNFHTMG 1170 QRPSYATLRM 1180 QPRPGLRPTG 1190 LVQNQPNQLR 1200 LQLQHRLQAQ 1210 QNRQPLMNQI 1220 SNVSNVNLTL 1230 RPGVPTQAPI 1240 NAQMLAQRQR 1250 EILNQHLRQR 1260 QMHQQQQVQQ 1270 RTLMMRGQGL 1280 NMTPSMVAPS 1290 GMPATMSNPR 1300 IPQANAQQFP 1310 FPPNYGISQQ 1320 PDPGFTGATT 1330 PQSPLMSPRM 1340 AHTQSPMMQQ 1350 SQANPAYQAP 1360 SDINGWAQGN 1370 MGGNSMFSQQ 1380 SPPHFGQQAN 1390 TSMYSNNMNI 1400 NVSMATNTGG 1410 MSSMNQMTGQ 1420 ISMTSVTSVP 1430 TSGLSSMGPE 1440 QVNDPALRGG 1450 NLFPNQLPGM 1460 DMIKQEGDTT RKYC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0017162 aryl hydrocarbon receptor binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0140416 transcription regulator inhibitor activity
Biological Process GO:0015721 bile acid and bile salt transport
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0045475 locomotor rhythm
Biological Process GO:0042789 mRNA transcription by RNA polymerase II
Biological Process GO:0045879 negative regulation of smoothened signaling pathway
Biological Process GO:0035357 peroxisome proliferator activated receptor signaling pathway
Biological Process GO:1904179 positive regulation of adipose tissue development
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1900076 regulation of cellular response to insulin stimulus
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0010906 regulation of glucose metabolic process
Biological Process GO:0019216 regulation of lipid metabolic process

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.