Search Results
Overview
| Uniprot ID | Q15599 |
|---|---|
| Protein Name | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 |
| Gene Name | NHERF2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 29 | GFHLHGEKGRRGQFI |
Function
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus
Protein Sequence
10
MAAPEPLRPR
20
LCRLVRGEQG
30
YGFHLHGEKG
40
RRGQFIRRVE
50
PGSPAEAAAL
60
RAGDRLVEVN
70
GVNVEGETHH
80
QVVQRIKAVE
90
GQTRLLVVDQ
100
ETDEELRRRQ
110
LTCTEEMAQR
120
GLPPAHDPWE
130
PKPDWAHTGS
140
HSSEAGKKDV
150
SGPLRELRPR
160
LCHLRKGPQG
170
YGFNLHSDKS
180
RPGQYIRSVD
190
PGSPAARSGL
200
RAQDRLIEVN
210
GQNVEGLRHA
220
EVVASIKARE
230
DEARLLVVDP
240
ETDEHFKRLR
250
VTPTEEHVEG
260
PLPSPVTNGT
270
SPAQLNGGSA
280
CSSRSDLPGS
290
DKDTEDGSAW
300
KQDPFQESGL
310
HLSPTAAEAK
320
EKARAMRVNK
330
RAPQMDWNRK
REIFSNF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0012505 | endomembrane system |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019902 | phosphatase binding |
| Molecular Function | GO:0043495 | protein-membrane adaptor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0031799 | type 2 metabotropic glutamate receptor binding |
| Molecular Function | GO:0031800 | type 3 metabotropic glutamate receptor binding |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0045296 | cadherin binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.