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Overview

Uniprot IDQ15631
Protein NameTranslin
Gene NameTSN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
187 GFRLLNLKNDSLRKR
219 LSIRGFNKETAAACV
228 TAAACVEK*******
69 REHFGTVKTHLTSLK
76 KTHLTSLKTKFPAEQ

Function

DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots

Protein Sequence

10 MSVSEIFVEL 20 QGFLAAEQDI 30 REEIRKVVQS 40 LEQTAREILT 50 LLQGVHQGAG 60 FQDIPKRCLK 70 AREHFGTVKT 80 HLTSLKTKFP 90 AEQYYRFHEH 100 WRFVLQRLVF 110 LAAFVVYLET 120 ETLVTREAVT 130 EILGIEPDRE 140 KGFHLDVEDY 150 LSGVLILASE 160 LSRLSVNSVT 170 AGDYSRPLHI 180 STFINELDSG 190 FRLLNLKNDS 200 LRKRYDGLKY 210 DVKKVEEVVY 220 DLSIRGFNKE TAAACVEK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0004519 endonuclease activity
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0003697 single-stranded DNA binding
Biological Process GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
Biological Process GO:0030422 siRNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.