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Overview

Uniprot ID	Q15642
Protein Name	Cdc42-interacting protein 4
Gene Name	TRIP10
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
584	GWTRVRRKEGGEGYV
60	YLPKRPAKDDPESKF

Function

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL

Protein Sequence

10 MDWGTELWDQ 20 FEVLERHTQW 30 GLDLLDRYVK 40 FVKERTEVEQ 50 AYAKQLRSLV 60 KKYLPKRPAK 70 DDPESKFSQQ 80 QSFVQILQEV 90 NDFAGQRELV 100 AENLSVRVCL 110 ELTKYSQEMK 120 QERKMHFQEG 130 RRAQQQLENG 140 FKQLENSKRK 150 FERDCREAEK 160 AAQTAERLDQ 170 DINATKADVE 180 KAKQQAHLRS 190 HMAEESKNEY 200 AAQLQRFNRD 210 QAHFYFSQMP 220 QIFDKLQDMD 230 ERRATRLGAG 240 YGLLSEAELE 250 VVPIIAKCLE 260 GMKVAANAVD 270 PKNDSHVLIE 280 LHKSGFARPG 290 DVEFEDFSQP 300 MNRAPSDSSL 310 GTPSDGRPEL 320 RGPGRSRTKR 330 WPFGKKNKPR 340 PPPLSPLGGP 350 VPSALPNGPP 360 SPRSGRDPLA 370 ILSEISKSVK 380 PRLASFRSLR 390 GSRGTVVTED 400 FSHLPPEQQR 410 KRLQQQLEER 420 SRELQKEVDQ 430 REALKKMKDV 440 YEKTPQMGDP 450 ASLEPQIAET 460 LSNIERLKLE 470 VQKYEAWLAE 480 AESRVLSNRG 490 DSLSRHARPP 500 DPPASAPPDS 510 SSNSASQDTK 520 ESSEEPPSEE 530 SQDTPIYTEF 540 DEDFEEEPTS 550 PIGHCVAIYH 560 FEGSSEGTIS 570 MAEGEDLSLM 580 EEDKGDGWTR 590 VRRKEGGEGY 600 VPTSYLRVTL N

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0001891	phagocytic cup
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0008289	lipid binding
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0007154	cell communication
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0007165	signal transduction

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.