Search Results

Overview

Uniprot IDQ15650
Protein NameActivating signal cointegrator 1
Gene NameTRIP4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
148 NSVKKKTKFVNLYTR
268 KAIKHKDKLLEFDRT

Function

Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription (PubMed:10454579, PubMed:25219498). May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (PubMed:10454579, PubMed:25219498). Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 (PubMed:12077347). Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773)

Protein Sequence

10 MAVAGAVSGE 20 PLVHWCTQQL 30 RKTFGLDVSE 40 EIIQYVLSIE 50 SAEEIREYVT 60 DLLQGNEGKK 70 GQFIEELITK 80 WQKNDQELIS 90 DPLQQCFKKD 100 EILDGQKSGD 110 HLKRGRKKGR 120 NRQEVPAFTE 130 PDTTAEVKTP 140 FDLAKAQENS 150 NSVKKKTKFV 160 NLYTREGQDR 170 LAVLLPGRHP 180 CDCLGQKHKL 190 INNCLICGRI 200 VCEQEGSGPC 210 LFCGTLVCTH 220 EEQDILQRDS 230 NKSQKLLKKL 240 MSGVENSGKV 250 DISTKDLLPH 260 QELRIKSGLE 270 KAIKHKDKLL 280 EFDRTSIRRT 290 QVIDDESDYF 300 ASDSNQWLSK 310 LERETLQKRE 320 EELRELRHAS 330 RLSKKVTIDF 340 AGRKILEEEN 350 SLAEYHSRLD 360 ETIQAIANGT 370 LNQPLTKLDR 380 SSEEPLGVLV 390 NPNMYQSPPQ 400 WVDHTGAASQ 410 KKAFRSSGFG 420 LEFNSFQHQL 430 RIQDQEFQEG 440 FDGGWCLSVH 450 QPWASLLVRG 460 IKRVEGRSWY 470 TPHRGRLWIA 480 ATAKKPSPQE 490 VSELQATYRL 500 LRGKDVEFPN 510 DYPSGCLLGC 520 VDLIDCLSQK 530 QFKEQFPDIS 540 QESDSPFVFI 550 CKNPQEMVVK 560 FPIKGNPKIW 570 KLDSKIHQGA 580 KKGLMKQNKA V

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0180022 RQC-trigger complex
Molecular Function GO:0035035 histone acetyltransferase binding
Molecular Function GO:0030331 nuclear estrogen receptor binding
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0002020 protease binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0044389 ubiquitin-like protein ligase binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030520 estrogen receptor signaling pathway
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0045661 regulation of myoblast differentiation
Biological Process GO:0072344 rescue of stalled cytosolic ribosome
Biological Process GO:0032790 ribosome disassembly
Biological Process GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.