Search Results

Overview

Uniprot IDQ15652
Protein NameJumonji domain-containing protein 1C
Gene NameJMJD1C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1038 DVAPFTTKIKGLEGE
1040 APFTTKIKGLEGERE
1060 ASSSSSPKSHIIKQD
1258 PTLIPEPKDSQANFK
1284 RPNNNLSKEKTEWHV
1326 PAMQLASKDRVSERS
1339 RSSAGAHKTDCLKLA
1344 AHKTDCLKLAEAGET
1367 NSDSVHTKSEKNFQA
1370 SVHTKSEKNFQAVSQ
1445 VSQPVAQKQECKVST
1449 VAQKQECKVSTTAPV
1483 TTDFIHLKKHKAALA
1484 TDFIHLKKHKAALAA
1486 FIHLKKHKAALAAAQ
1495 ALAAAQYKSSNASET
1606 DSKIIVDKYVKDDKV
1661 QNDLQKRKGEIEEDL
1685 AKERSKLKLQSNSNT
1741 CRLIRSKKGEEPAHS
2076 LLTTTAGKLRVGSTD
2120 IASVVENKIPPSKTS
2128 IPPSKTSKINVKPEL
2252 VSKRQKNKSGETVVL
2360 KGNGILSKAGILKKF
315 SIRPNKRKGSDSSIP
404 PENELKNKNTSKING
408 LKNKNTSKINGEEGK
536 FGLQTLQKMDPNVSD
545 DPNVSDSKHSIANAK
552 KHSIANAKFLETAKK
559 KFLETAKKDSDQSWV
626 PPETIKSKLNTSVDT
635 NTSVDTHKIKSSPSP
637 SVDTHKIKSSPSPEV
659 SPDSVKSKATYVNSQ
676 GERRLANKIEHELSR
707 KSPLIIDKNEHFTVY
976 SVASTSAKNDLDLNR
988 LNRSQTGKDCHLHRH

Function

Demethylates lysine in proteins, such as STAT3 or MDC1 (By similarity) (PubMed:24240613). Demethylates MDC1, thereby promoting MDC1-RNF8 interaction and facilitating RNF8-dependent MDC1 ubiquitination essential for double-strand break (DSB) repair (PubMed:24240613). Demethylation of STAT3 at 'Lys-140' facilitates its interactions with the phosphatase PTPN6 and restrains STAT3 activation (By similarity). It is uncertain whether JMJD1C removes methyl groups from histone proteins as the other JMJD1/KDM3 proteins do (PubMed:23593242, PubMed:24240613, PubMed:32034158). Nevertheless, JMJD1C may act as a context-specific histone demethylase. Implicated in lipogenic gene transcription in the liver, where USF1 recruits JMJD1C to lipogenic promoters in response to insulin or feeding stimuli, thereby potentially promoting H3K9me2 demethylation and enhancing chromatin accessibility (PubMed:32034158). Post-translational modifications may regulate JMJD1C's enzymatic activity, contributing to its context-specific functions (PubMed:32034158). Alternatively, JMJD1C may influence chromatin regulation indirectly, acting as a scaffold or co-regulator that recruits or stabilizes other active demethylase complexes modifying histone marks (PubMed:24240613). Plays an indispensable role in spermatogenesis (By similarity)

Protein Sequence

10 MAVETRAELV 20 GKRFLCVAVG 30 DEARSERWES 40 GRGWRSWRAG 50 VIRAVSHRDS 60 RNPDLAVYVE 70 FDDLEWDKRE 80 WVKVYEDFST 90 FLVEYHLIWA 100 KRNDPSQTQG 110 SKSKQIQWPA 120 LTFKPLVERN 130 IPSSVTAVEF 140 LVDKQLDFLT 150 EDSAFQPYQD 160 DIDSLNPVLR 170 DNPQLHEEVK 180 VWVKEQKVQE 190 IFMQGPYSLN 200 GYRVRVYRQD 210 SATQWFTGII 220 THHDLFTRTM 230 IVMNDQVLEP 240 QNVDPSMVQM 250 TFLDDVVHSL 260 LKGENIGITS 270 RRRSRANQNV 280 NAVHSHYTRA 290 QANSPRPAMN 300 SQAAVPKQNT 310 HQQQQQRSIR 320 PNKRKGSDSS 330 IPDEEKMKEE 340 KYDYISRGEN 350 PKGKNKHLMN 360 KRRKPEEDEK 370 KLNMKRLRTD 380 NVSDFSESSD 390 SENSNKRIID 400 NSSEQKPENE 410 LKNKNTSKIN 420 GEEGKPHNNE 430 KAGEETLKNS 440 QPPWDQIQED 450 KKHEEAEKRK 460 SVDTQLQEDM 470 IIHSSEQSTV 480 SDHNSNDLLP 490 QECNMDKTHT 500 MELLPKEKFV 510 SRPPTPKCVI 520 DITNDTNLEK 530 VAQENSSTFG 540 LQTLQKMDPN 550 VSDSKHSIAN 560 AKFLETAKKD 570 SDQSWVSDVV 580 KVDLTQSSVT 590 NASSGNDHLN 600 MEKEKYVSYI 610 SPLSAVSVME 620 DKLHKRSPPP 630 ETIKSKLNTS 640 VDTHKIKSSP 650 SPEVVKPKIT 660 HSPDSVKSKA 670 TYVNSQATGE 680 RRLANKIEHE 690 LSRCSFHPIP 700 TRSSTLETTK 710 SPLIIDKNEH 720 FTVYRDPALI 730 GSETGANHIS 740 PFLSQHPFPL 750 HSSSHRTCLN 760 PGTHHPALTP 770 APHLLAGSSS 780 QTPLPTINTH 790 PLTSGPHHAV 800 HHPHLLPTVL 810 PGVPTASLLG 820 GHPRLESAHA 830 SSLSHLALAH 840 QQQQQLLQHQ 850 SPHLLGQAHP 860 SASYNQLGLY 870 PIIWQYPNGT 880 HAYSGLGLPS 890 SKWVHPENAV 900 NAEASLRRNS 910 PSPWLHQPTP 920 VTSADGIGLL 930 SHIPVRPSSA 940 EPHRPLKITA 950 HSSPPLTKTL 960 VDHHKEELER 970 KAFMEPLRSV 980 ASTSAKNDLD 990 LNRSQTGKDC 1000 HLHRHFVDPV 1010 LNQLQRPPQE 1020 TGERLNKYKE 1030 EHRRILQESI 1040 DVAPFTTKIK 1050 GLEGERENYS 1060 RVASSSSSPK 1070 SHIIKQDMDV 1080 ERSVSDLYKM 1090 KHSVPQSLPQ 1100 SNYFTTLSNS 1110 VVNEPPRSYP 1120 SKEVSNIYGD 1130 KQSNALAAAA 1140 ANPQTLTSFI 1150 TSLSKPPPLI 1160 KHQPESEGLV 1170 GKIPEHLPHQ 1180 IASHSVTTFR 1190 NDCRSPTHLT 1200 VSSTNTLRSM 1210 PALHRAPVFH 1220 PPIHHSLERK 1230 EGSYSSLSPP 1240 TLTPVMPVNA 1250 GGKVQESQKP 1260 PTLIPEPKDS 1270 QANFKSSSEQ 1280 SLTEMWRPNN 1290 NLSKEKTEWH 1300 VEKSSGKLQA 1310 AMASVIVRPS 1320 SSTKTDSMPA 1330 MQLASKDRVS 1340 ERSSAGAHKT 1350 DCLKLAEAGE 1360 TGRIILPNVN 1370 SDSVHTKSEK 1380 NFQAVSQGSV 1390 PSSVMSAVNT 1400 MCNTKTDVIT 1410 SAADTTSVSS 1420 WGGSEVISSL 1430 SNTILASTSS 1440 ECVSSKSVSQ 1450 PVAQKQECKV 1460 STTAPVTLAS 1470 SKTGSVVQPS 1480 SGFSGTTDFI 1490 HLKKHKAALA 1500 AAQYKSSNAS 1510 ETEPNAIKNQ 1520 TLSASLPLDS 1530 TVICSTINKA 1540 NSVGNGQASQ 1550 TSQPNYHTKL 1560 KKAWLTRHSE 1570 EDKNTNKMEN 1580 SGNSVSEIIK 1590 PCSVNLIAST 1600 SSDIQNSVDS 1610 KIIVDKYVKD 1620 DKVNRRKAKR 1630 TYESGSESGD 1640 SDESESKSEQ 1650 RTKRQPKPTY 1660 KKKQNDLQKR 1670 KGEIEEDLKP 1680 NGVLSRSAKE 1690 RSKLKLQSNS 1700 NTGIPRSVLK 1710 DWRKVKKLKQ 1720 TGESFLQDDS 1730 CCEIGPNLQK 1740 CRECRLIRSK 1750 KGEEPAHSPV 1760 FCRFYYFRRL 1770 SFSKNGVVRI 1780 DGFSSPDQYD 1790 DEAMSLWTHE 1800 NFEDDELDIE 1810 TSKYILDIIG 1820 DKFCQLVTSE 1830 KTALSWVKKD 1840 AKIAWKRAVR 1850 GVREMCDACE 1860 ATLFNIHWVC 1870 QKCGFVVCLD 1880 CYKAKERKSS 1890 RDKELYAWMK 1900 CVKGQPHDHK 1910 HLMPTQIIPG 1920 SVLTDLLDAM 1930 HTLREKYGIK 1940 SHCHCTNKQN 1950 LQVGNFPTMN 1960 GVSQVLQNVL 1970 NHSNKISLCM 1980 PESQQQNTPP 1990 KSEKNGGSSP 2000 ESDVGTDNKL 2010 TPPESQSPLH 2020 WLADLAEQKA 2030 REEKKENKEL 2040 TLENQIKEER 2050 EQDNSESPNG 2060 RTSPLVSQNN 2070 EQGSTLRDLL 2080 TTTAGKLRVG 2090 STDAGIAFAP 2100 VYSMGAPSSK 2110 SGRTMPNILD 2120 DIIASVVENK 2130 IPPSKTSKIN 2140 VKPELKEEPE 2150 ESIISAVDEN 2160 NKLYSDIPHS 2170 WICEKHILWL 2180 KDYKNSSNWK 2190 LFKECWKQGQ 2200 PAVVSGVHKK 2210 MNISLWKAES 2220 ISLDFGDHQA 2230 DLLNCKDSII 2240 SNANVKEFWD 2250 GFEEVSKRQK 2260 NKSGETVVLK 2270 LKDWPSGEDF 2280 KTMMPARYED 2290 LLKSLPLPEY 2300 CNPEGKFNLA 2310 SHLPGFFVRP 2320 DLGPRLCSAY 2330 GVVAAKDHDI 2340 GTTNLHIEVS 2350 DVVNILVYVG 2360 IAKGNGILSK 2370 AGILKKFEEE 2380 DLDDILRKRL 2390 KDSSEIPGAL 2400 WHIYAGKDVD 2410 KIREFLQKIS 2420 KEQGLEVLPE 2430 HDPIRDQSWY 2440 VNKKLRQRLL 2450 EEYGVRTCTL 2460 IQFLGDAIVL 2470 PAGALHQVQN 2480 FHSCIQVTED 2490 FVSPEHLVES 2500 FHLTQELRLL 2510 KEEINYDDKL 2520 QVKNILYHAV 2530 KEMVRALKIH 2540 EDEVEDMEEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0031490 chromatin DNA binding
Molecular Function GO:0051213 dioxygenase activity
Molecular Function GO:0032454 histone H3K9 demethylase activity
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0140457 protein demethylase activity
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0007596 blood coagulation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0008610 lipid biosynthetic process
Biological Process GO:0002317 plasma cell differentiation
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.