Search Results
Overview
| Uniprot ID | Q15654 |
|---|---|
| Protein Name | Thyroid receptor-interacting protein 6 |
| Gene Name | TRIP6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 262 | ELDRLTKKLVHDMNH |
Function
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor
Protein Sequence
10
MSGPTWLPPK
20
QPEPARAPQG
30
RAIPRGTPGP
40
PPAHGAALQP
50
HPRVNFCPLP
60
SEQCYQAPGG
70
PEDRGPAWVG
80
SHGVLQHTQG
90
LPADRGGLRP
100
GSLDAEIDLL
110
SSTLAELNGG
120
RGHASRRPDR
130
QAYEPPPPPA
140
YRTGSLKPNP
150
ASPLPASPYG
160
GPTPASYTTA
170
STPAGPAFPV
180
QVKVAQPVRG
190
CGPPRRGASQ
200
ASGPLPGPHF
210
PLPGRGEVWG
220
PGYRSQREPG
230
PGAKEEAAGV
240
SGPAGRGRGG
250
EHGPQVPLSQ
260
PPEDELDRLT
270
KKLVHDMNHP
280
PSGEYFGQCG
290
GCGEDVVGDG
300
AGVVALDRVF
310
HVGCFVCSTC
320
RAQLRGQHFY
330
AVERRAYCEG
340
CYVATLEKCA
350
TCSQPILDRI
360
LRAMGKAYHP
370
GCFTCVVCHR
380
GLDGIPFTVD
390
ATSQIHCIED
400
FHRKFAPRCS
410
VCGGAIMPEP
420
GQEETVRIVA
430
LDRSFHIGCY
440
KCEECGLLLS
450
SEGECQGCYP
460
LDGHILCKAC
470
SAWRIQELSA
TVTTDC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0005149 | interleukin-1 receptor binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0046966 | nuclear thyroid hormone receptor binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0043009 | chordate embryonic development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0048041 | focal adhesion assembly |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.