Search Results
Overview
| Uniprot ID | Q15699 |
|---|---|
| Protein Name | ALX homeobox protein 1 |
| Gene Name | ALX1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 48 | YSKASAGKCVQAFGP |
| 7 | *MEFLSEKFALKSPP |
Function
Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:8756334, PubMed:9753625). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509)
Protein Sequence
10
MEFLSEKFAL
20
KSPPSKNSDF
30
YMGAGGPLEH
40
VMETLDNESF
50
YSKASAGKCV
60
QAFGPLPRAE
70
HHVRLERTSP
80
CQDSSVNYGI
90
TKVEGQPLHT
100
ELNRAMDNCN
110
SLRMSPVKGM
120
QEKGELDELG
130
DKCDSNVSSS
140
KKRRHRTTFT
150
SLQLEELEKV
160
FQKTHYPDVY
170
VREQLALRTE
180
LTEARVQVWF
190
QNRRAKWRKR
200
ERYGQIQQAK
210
SHFAATYDIS
220
VLPRTDSYPQ
230
IQNNLWAGNA
240
SGGSVVTSCM
250
LPRDTSSCMT
260
PYSHSPRTDS
270
SYTGFSNHQN
280
QFSHVPLNNF
290
FTDSLLTGAT
300
NGHAFETKPE
310
FERRSSSIAV
320
LRMKAKEHTA
NISWAM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0048704 | embryonic skeletal system morphogenesis |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0048666 | neuron development |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.