Search Results
Overview
| Uniprot ID | Q15738 |
|---|---|
| Protein Name | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating |
| Gene Name | NSDHL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 31 | KVNADIEKVNQNQAK |
| 38 | KVNQNQAKRCTVIGG |
Function
Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis (By similarity). Also plays a role in the regulation of the endocytic trafficking of EGFR (By similarity)
Protein Sequence
10
MEPAVSEPMR
20
DQVARTHLTE
30
DTPKVNADIE
40
KVNQNQAKRC
50
TVIGGSGFLG
60
QHMVEQLLAR
70
GYAVNVFDIQ
80
QGFDNPQVRF
90
FLGDLCSRQD
100
LYPALKGVNT
110
VFHCASPPPS
120
SNNKELFYRV
130
NYIGTKNVIE
140
TCKEAGVQKL
150
ILTSSASVIF
160
EGVDIKNGTE
170
DLPYAMKPID
180
YYTETKILQE
190
RAVLGANDPE
200
KNFLTTAIRP
210
HGIFGPRDPQ
220
LVPILIEAAR
230
NGKMKFVIGN
240
GKNLVDFTFV
250
ENVVHGHILA
260
AEQLSRDSTL
270
GGKAFHITND
280
EPIPFWTFLS
290
RILTGLNYEA
300
PKYHIPYWVA
310
YYLALLLSLL
320
VMVISPVIQL
330
QPTFTPMRVA
340
LAGTFHYYSC
350
ERAKKAMGYQ
360
PLVTMDDAME
370
RTVQSFRHLR
RVK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005811 | lipid droplet |
| Molecular Function | GO:0003854 | 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity |
| Molecular Function | GO:0102175 | 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity |
| Molecular Function | GO:0000252 | 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.