Search Results
Overview
| Uniprot ID | Q15742 |
|---|---|
| Protein Name | NGFI-A-binding protein 2 |
| Gene Name | NAB2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 269 | GEVTSLLKLNKKLAR |
| 361 | STYLSSLKGSRLHPE |
| 376 | ELGGPPLKKLKQEVG |
| 377 | LGGPPLKKLKQEVGE |
Function
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity)
Protein Sequence
10
MHRAPSPTAE
20
QPPGGGDSAR
30
RTLQPRLKPS
40
ARAMALPRTL
50
GELQLYRVLQ
60
RANLLSYYET
70
FIQQGGDDVQ
80
QLCEAGEEEF
90
LEIMALVGMA
100
TKPLHVRRLQ
110
KALREWATNP
120
GLFSQPVPAV
130
PVSSIPLFKI
140
SETAGTRKGS
150
MSNGHGSPGE
160
KAGSARSFSP
170
KSPLELGEKL
180
SPLPGGPGAG
190
DPRIWPGRST
200
PESDVGAGGE
210
EEAGSPPFSP
220
PAGGGVPEGT
230
GAGGLAAGGT
240
GGGPDRLEPE
250
MVRMVVESVE
260
RIFRSFPRGD
270
AGEVTSLLKL
280
NKKLARSVGH
290
IFEMDDNDSQ
300
KEEEIRKYSI
310
IYGRFDSKRR
320
EGKQLSLHEL
330
TINEAAAQFC
340
MRDNTLLLRR
350
VELFSLSRQV
360
ARESTYLSSL
370
KGSRLHPEEL
380
GGPPLKKLKQ
390
EVGEQSHPEI
400
QQPPPGPESY
410
VPPYRPSLEE
420
DSASLSGESL
430
DGHLQAVGSC
440
PRLTPPPADL
450
PLALPAHGLW
460
SRHILQQTLM
470
DEGLRLARLV
480
SHDRVGRLSP
490
CVPAKPPLAE
500
FEEGLLDRCP
510
APGPHPALVE
520
GRRSSVKVEA
EASRQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0016480 | negative regulation of transcription by RNA polymerase III |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.