Search Results

Overview

Uniprot ID	Q15785
Protein Name	Mitochondrial import receptor subunit TOM34
Gene Name	TOMM34
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
181	SKETTATKNRVPSAG
206	EGNELVKKGNHKKAI
4	****MAPKFPDSVEE

Function

Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state

Protein Sequence

10 MAPKFPDSVE 20 ELRAAGNESF 30 RNGQYAEASA 40 LYGRALRVLQ 50 AQGSSDPEEE 60 SVLYSNRAAC 70 HLKDGNCRDC 80 IKDCTSALAL 90 VPFSIKPLLR 100 RASAYEALEK 110 YPMAYVDYKT 120 VLQIDDNVTS 130 AVEGINRMTR 140 ALMDSLGPEW 150 RLKLPSIPLV 160 PVSAQKRWNS 170 LPSENHKEMA 180 KSKSKETTAT 190 KNRVPSAGDV 200 EKARVLKEEG 210 NELVKKGNHK 220 KAIEKYSESL 230 LCSNLESATY 240 SNRALCYLVL 250 KQYTEAVKDC 260 TEALKLDGKN 270 VKAFYRRAQA 280 HKALKDYKSS 290 FADISNLLQI 300 EPRNGPAQKL RQEVKQNLH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0031072	heat shock protein binding
Biological Process	GO:0006626	protein targeting to mitochondrion

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.