Overview
| Uniprot ID | Q157S1 |
|---|
| Protein Name | CREB-regulated transcription coactivator 1 |
|---|
| Gene Name | Crtc1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 123 |
RRPLSVDKHGRQADS |
Function
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock (By similarity)
Protein Sequence
10
MATSNNPRKF
20
SEKIALHNQK
30
QAEETAAFEE
40
VMKDLSLTRA
50
ARLQLQKSQY
60
LQLGPSRGQY
70
YGGSLPNVNQ
80
IGSSSMDLSF
90
QTPFQSSGLD
100
TSRTTRHHGL
110
VDRVYRERGR
120
LGSPHRRPLS
130
VDKHGRQADS
140
CPYGTVYLSP
150
PADTSWRRTN
160
SDSALHQSTM
170
TPTQAESFTG
180
GPQDAHQKRV
190
LLLTVPGMEE
200
TGSETDKTLS
210
KQSWDSKKAG
220
SRPKSCEVPG
230
INIFPSADQE
240
NTAALIPATH
250
NTGGSLPDLS
260
TIHFPSPLPT
270
PLDPEEPPFP
280
ALTSSGSTGS
290
LAHLGVGGTG
300
QGMNTPSSSP
310
QRRPAVVSPL
320
SLSTEARRQQ
330
AQQVPPTLSP
340
LSPITQAVAM
350
DALSLEQQLP
360
YAFFTQAGSQ
370
QPPPQPQPPP
380
PPPPVSQQQP
390
PPPQVSVGLP
400
QGGPLLPSAS
410
LTRGPQLPPL
420
AVTVPSTLPQ
430
SPTESPGQPP
440
MGIDVTSAPA
450
LQYRTGAGSP
460
ATQSPTSPVS
470
NQGFSPGSSP
480
QHTSTLGSVF
490
GDAYYEQQMT
500
ARQANALSRQ
510
LEQFNMMENA
520
ISSSSLYNPG
530
STLNYSQAAM
540
MGLSGSHGGL
550
QDPQQLGYAG
560
HGGIPNIILT
570
VTGESPPSLS
580
KELSSTLAGV
590
SDVSFDSDHQ
600
FPLDELKIDP
610
LTLDGLHMLN
620
DPDMVLADPA
630
TEDTFRMDRL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Molecular Function |
GO:0008140 |
cAMP response element binding protein binding |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Biological Process |
GO:0071320 |
cellular response to cAMP |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0097009 |
energy homeostasis |
| Biological Process |
GO:0043153 |
entrainment of circadian clock by photoperiod |
| Biological Process |
GO:0007613 |
memory |
| Biological Process |
GO:1902631 |
negative regulation of membrane hyperpolarization |
| Biological Process |
GO:1900006 |
positive regulation of dendrite development |
| Biological Process |
GO:1900273 |
positive regulation of long-term synaptic potentiation |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0099527 |
postsynapse to nucleus signaling pathway |
| Biological Process |
GO:0051289 |
protein homotetramerization |
| Biological Process |
GO:0048511 |
rhythmic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.