Search Results

Overview

Uniprot ID	Q15833
Protein Name	Syntaxin-binding protein 2
Gene Name	STXBP2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
331	KDLSQILKKMPQYQK
523	FGHWHKNKAGIEARA

Function

Functions in intracellular vesicle trafficking through interaction with SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) which are essential proteins for membrane fusion. By promoting the assembly of functional STX11/SNAP23/VAMP8 SNARE complexes at the plasma membrane, regulates cytotoxic granule exocytosis in natural killer (NK) cells

Protein Sequence

10 MAPSGLKAVV 20 GEKILSGVIR 30 SVKKDGEWKV 40 LIMDHPSMRI 50 LSSCCKMSDI 60 LAEGITIVED 70 INKRREPIPS 80 LEAIYLLSPT 90 EKSVQALIKD 100 FQGTPTFTYK 110 AAHIFFTDTC 120 PEPLFSELGR 130 SRLAKVVKTL 140 KEIHLAFLPY 150 EAQVFSLDAP 160 HSTYNLYCPF 170 RAEERTRQLE 180 VLAQQIATLC 190 ATLQEYPAIR 200 YRKGPEDTAQ 210 LAHAVLAKLN 220 AFKADTPSLG 230 EGPEKTRSQL 240 LIMDRAADPV 250 SPLLHELTFQ 260 AMAYDLLDIE 270 QDTYRYETTG 280 LSEAREKAVL 290 LDEDDDLWVE 300 LRHMHIADVS 310 KKVTELLRTF 320 CESKRLTTDK 330 ANIKDLSQIL 340 KKMPQYQKEL 350 NKYSTHLHLA 360 DDCMKHFKGS 370 VEKLCSVEQD 380 LAMGSDAEGE 390 KIKDSMKLIV 400 PVLLDAAVPA 410 YDKIRVLLLY 420 ILLRNGVSEE 430 NLAKLIQHAN 440 VQAHSSLIRN 450 LEQLGGTVTN 460 PGGSGTSSRL 470 EPRERMEPTY 480 QLSRWTPVIK 490 DVMEDAVEDR 500 LDRNLWPFVS 510 DPAPTASSQA 520 AVSARFGHWH 530 KNKAGIEARA 540 GPRLIVYVMG 550 GVAMSEMRAA 560 YEVTRATEGK 570 WEVLIGSSHI 580 LTPTRFLDDL 590 KALDKKLEDI ALP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0042582	azurophil granule
Cellular Component	GO:0044194	cytolytic granule
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0045335	phagocytic vesicle
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098793	presynapse
Cellular Component	GO:0030141	secretory granule
Cellular Component	GO:0042581	specific granule
Cellular Component	GO:0070820	tertiary granule
Cellular Component	GO:0042589	zymogen granule membrane
Molecular Function	GO:0017075	syntaxin-1 binding
Molecular Function	GO:0030348	syntaxin-3 binding
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0001909	leukocyte mediated cytotoxicity
Biological Process	GO:0043312	neutrophil degranulation
Biological Process	GO:0099525	presynaptic dense core vesicle exocytosis
Biological Process	GO:0043304	regulation of mast cell degranulation
Biological Process	GO:0006904	vesicle docking involved in exocytosis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.