Search Results
Overview
| Uniprot ID | Q15906 |
|---|---|
| Protein Name | Vacuolar protein sorting-associated protein 72 homolog |
| Gene Name | VPS72 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | LKSLRPRKVNTPAGS |
| 228 | LVGEPGPKEENVDIE |
| 87 | RKRRVVTKAYKEPLK |
Function
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling
Protein Sequence
10
MSLAGGRAPR
20
KTAGNRLSGL
30
LEAEEEDEFY
40
QTTYGGFTEE
50
SGDDEYQGDQ
60
SDTEDEVDSD
70
FDIDEGDEPS
80
SDGEAEEPRR
90
KRRVVTKAYK
100
EPLKSLRPRK
110
VNTPAGSSQK
120
AREEKALLPL
130
ELQDDGSDSR
140
KSMRQSTAEH
150
TRQTFLRVQE
160
RQGQSRRRKG
170
PHCERPLTQE
180
ELLREAKITE
190
ELNLRSLETY
200
ERLEADKKKQ
210
VHKKRKCPGP
220
IITYHSVTVP
230
LVGEPGPKEE
240
NVDIEGLDPA
250
PSVSALTPHA
260
GTGPVNPPAR
270
CSRTFITFSD
280
DATFEEWFPQ
290
GRPPKVPVRE
300
VCPVTHRPAL
310
YRDPVTDIPY
320
ATARAFKIIR
330
EAYKKYITAH
340
GLPPTASALG
350
PGPPPPEPLP
360
GSGPRALRQK
IVIK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0000812 | Swr1 complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0140713 | histone chaperone activity |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:2000779 | regulation of double-strand break repair |
| Biological Process | GO:0045815 | transcription initiation-coupled chromatin remodeling |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.