Search Results

Overview

Uniprot IDQ15911
Protein NameZinc finger homeobox protein 3
Gene NameZFHX3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2947 SGDRPGQKRFRTQMT

Function

Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010)

Protein Sequence

10 MEGCDSPVVS 20 GKDNGCGIPQ 30 HQQWTELNST 40 HLPDKPSSME 50 QSTGESHGPL 60 DSLRAPFNER 70 LAESTASAGP 80 PSEPASKEVT 90 CNECSASFAS 100 LQTYMEHHCP 110 SARPPPPLRE 120 ESASDTGEEG 130 DEESDVENLA 140 GEIVYQPDGS 150 AYIVESLSQL 160 TQGGGACGSG 170 SGSGPLPSLF 180 LNSLPGAGGK 190 QGDPSCAAPV 200 YPQIINTFHI 210 ASSFGKWFEG 220 PDQAFPNTSA 230 LAGLSPVLHS 240 FRVFDVRHKS 250 NKDYLNSDGS 260 AKSSCVSKDV 270 PNNVDLSKFD 280 GFVLYGKRKP 290 ILMCFLCKLS 300 FGYVRSFVTH 310 AVHDHRMTLS 320 EDERKILSNK 330 NISAIIQGIG 340 KDKEPLVSFL 350 EPKNKNFQHP 360 LVSTANLIGP 370 GHSFYGKFSG 380 IRMEGEEALP 390 AGSAAGPEQP 400 QAGLLTPSTL 410 LNLGGLTSSV 420 LKTPITSVPL 430 GPLASSPTKS 440 SEGKDSGAAE 450 GEKQEVGDGD 460 CFSEKVEPAE 470 EEAEEEEEEE 480 EAEEEEEEEE 490 EEEEEEEDEG 500 CKGLFPSELD 510 EELEDRPHEE 520 PGAAAGSSSK 530 KDLALSNQSI 540 SNSPLMPNVL 550 QTLSRGTAST 560 SSNSASSFVV 570 FDGANRRNRL 580 SFNSEGVRAN 590 VAEGGRRLDF 600 ADESANKDNA 610 TAPEPNESTE 620 GDDGGFVPHH 630 QHAGSLCELG 640 VGECPSGSGV 650 ECPKCDTVLG 660 SSRSLGGHMT 670 MMHSRNSCKT 680 LKCPKCNWHY 690 KYQQTLEAHM 700 KEKHPEPGGS 710 CVYCKSGQPH 720 PRLARGESYT 730 CGYKPFRCEV 740 CNYSTTTKGN 750 LSIHMQSDKH 760 LNNMQNLQNG 770 GGEQVFSHTA 780 GAAAAAVAAA 790 AAAANISSSC 800 GAPSPTKPKT 810 KPTWRCEVCD 820 YETNVARNLR 830 IHMTSEKHMH 840 NMMLLQQNMT 850 QIQHNRHLGL 860 GSLPSPAEAE 870 LYQYYLAQNM 880 NLPNLKMDSA 890 ASDAQFMMSG 900 FQLDPAGPMA 910 AMTPALVGGE 920 IPLDMRLGGG 930 QLVSEELMNL 940 GESFIQTNDP 950 SLKLFQCAVC 960 NKFTTDNLDM 970 LGLHMNVERS 980 LSEDEWKAVM 990 GDSYQCKLCR 1000 YNTQLKANFQ 1010 LHCKTDKHVQ 1020 KYQLVAHIKE 1030 GGKANEWRLK 1040 CVAIGNPVHL 1050 KCNACDYYTN 1060 SLEKLRLHTV 1070 NSRHEASLKL 1080 YKHLQQHESG 1090 VEGESCYYHC 1100 VLCNYSTKAK 1110 LNLIQHVRSM 1120 KHQRSESLRK 1130 LQRLQKGLPE 1140 EDEDLGQIFT 1150 IRRCPSTDPE 1160 EAIEDVEGPS 1170 ETAADPEELA 1180 KDQEGGASSS 1190 QAEKELTDSP 1200 ATSKRISFPG 1210 SSESPLSSKR 1220 PKTAEEIKPE 1230 QMYQCPYCKY 1240 SNADVNRLRV 1250 HAMTQHSVQP 1260 MLRCPLCQDM 1270 LNNKIHLQLH 1280 LTHLHSVAPD 1290 CVEKLIMTVT 1300 TPEMVMPSSM 1310 FLPAAVPDRD 1320 GNSNLEEAGK 1330 QPETSEDLGK 1340 NILPSASTEQ 1350 SGDLKPSPAD 1360 PGSVREDSGF 1370 ICWKKGCNQV 1380 FKTSAALQTH 1390 FNEVHAKRPQ 1400 LPVSDRHVYK 1410 YRCNQCSLAF 1420 KTIEKLQLHS 1430 QYHVIRAATM 1440 CCLCQRSFRT 1450 FQALKKHLET 1460 SHLELSEADI 1470 QQLYGGLLAN 1480 GDLLAMGDPT 1490 LAEDHTIIVE 1500 EDKEEESDLE 1510 DKQSPTGSDS 1520 GSVQEDSGSE 1530 PKRALPFRKG 1540 PNFTMEKFLD 1550 PSRPYKCTVC 1560 KESFTQKNIL 1570 LVHYNSVSHL 1580 HKLKRALQES 1590 ATGQPEPTSS 1600 PDNKPFKCNT 1610 CNVAYSQSST 1620 LEIHMRSVLH 1630 QTKARAAKLE 1640 AASGSSNGTG 1650 NSSSISLSSS 1660 TPSPVSTSGS 1670 NTFTTSNPSS 1680 AGIAPSSNLL 1690 SQVPTESVGM 1700 PPLGNPIGAN 1710 IASPSEPKEA 1720 NRKKLADMIA 1730 SRQQQQQQQQ 1740 QQQQQQQQQQ 1750 QAQTLAQAQA 1760 QVQAHLQQEL 1770 QQQAALIQSQ 1780 LFNPTLLPHF 1790 PMTTETLLQL 1800 QQQQHLLFPF 1810 YIPSAEFQLN 1820 PEVSLPVTSG 1830 ALTLTGTGPG 1840 LLEDLKAQVQ 1850 VPQQSHQQIL 1860 PQQQQNQLSI 1870 AQSHSALLQP 1880 SQHPEKKNKL 1890 VIKEKEKESQ 1900 RERDSAEGGE 1910 GNTGPKETLP 1920 DALKAKEKKE 1930 LAPGGGSEPS 1940 MLPPRIASDA 1950 RGNATKALLE 1960 NFGFELVIQY 1970 NENKQKVQKK 1980 NGKTDQGENL 1990 EKLECDSCGK 2000 LFSNILILKS 2010 HQEHVHQNYF 2020 PFKQLERFAK 2030 QYRDHYDKLY 2040 PLRPQTPEPP 2050 PPPPPPPPPP 2060 LPAAPPQPAS 2070 TPAIPASAPP 2080 ITSPTIAPAQ 2090 PSVPLTQLSM 2100 PMELPIFSPL 2110 MMQTMPLQTL 2120 PAQLPPQLGP 2130 VEPLPADLAQ 2140 LYQHQLNPTL 2150 LQQQNKRPRT 2160 RITDDQLRVL 2170 RQYFDINNSP 2180 SEEQIKEMAD 2190 KSGLPQKVIK 2200 HWFRNTLFKE 2210 RQRNKDSPYN 2220 FSNPPITSLE 2230 ELKIDSRPPS 2240 PEPPKQEYWG 2250 SKRSSRTRFT 2260 DYQLRVLQDF 2270 FDANAYPKDD 2280 EFEQLSNLLN 2290 LPTRVIVVWF 2300 QNARQKARKN 2310 YENQGEGKDG 2320 ERRELTNDRY 2330 IRTSNLNYQC 2340 KKCSLVFQRI 2350 FDLIKHQKKL 2360 CYKDEDEEGQ 2370 DDSQNEDSMD 2380 AMEILTPTSS 2390 SCSTPMPSQA 2400 YSAPAPSANN 2410 TASSAFLQLT 2420 AEAEELATFN 2430 SKTEAGDEKP 2440 KLAEAPSAQP 2450 NQTQEKQGQP 2460 KPELQQQEQP 2470 EQKTNTPQQK 2480 LPQLVSLPSL 2490 PQPPPQAPPP 2500 QCPLPQSSPS 2510 PSQLSHLPLK 2520 PLHTSTPQQL 2530 ANLPPQLIPY 2540 QCDQCKLAFP 2550 SFEHWQEHQQ 2560 LHFLSAQNQF 2570 IHPQFLDRSL 2580 DMPFMLFDPS 2590 NPLLASQLLS 2600 GAIPQIPASS 2610 ATSPSTPTST 2620 MNTLKRKLEE 2630 KASASPGEND 2640 SGTGGEEPQR 2650 DKRLRTTITP 2660 EQLEILYQKY 2670 LLDSNPTRKM 2680 LDHIAHEVGL 2690 KKRVVQVWFQ 2700 NTRARERKGQ 2710 FRAVGPAQAH 2720 RRCPFCRALF 2730 KAKTALEAHI 2740 RSRHWHEAKR 2750 AGYNLTLSAM 2760 LLDCDGGLQM 2770 KGDIFDGTSF 2780 SHLPPSSSDG 2790 QGVPLSPVSK 2800 TMELSPRTLL 2810 SPSSIKVEGI 2820 EDFESPSMSS 2830 VNLNFDQTKL 2840 DNDDCSSVNT 2850 AITDTTTGDE 2860 GNADNDSATG 2870 IATETKSSSA 2880 PNEGLTKAAM 2890 MAMSEYEDRL 2900 SSGLVSPAPS 2910 FYSKEYDNEG 2920 TVDYSETSSL 2930 ADPCSPSPGA 2940 SGSAGKSGDS 2950 GDRPGQKRFR 2960 TQMTNLQLKV 2970 LKSCFNDYRT 2980 PTMLECEVLG 2990 NDIGLPKRVV 3000 QVWFQNARAK 3010 EKKSKLSMAK 3020 HFGINQTSYE 3030 GPKTECTLCG 3040 IKYSARLSVR 3050 DHIFSQQHIS 3060 KVKDTIGSQL 3070 DKEKEYFDPA 3080 TVRQLMAQQE 3090 LDRIKKANEV 3100 LGLAAQQQGM 3110 FDNTPLQALN 3120 LPTAYPALQG 3130 IPPVLLPGLN 3140 SPSLPGFTPS 3150 NTALTSPKPN 3160 LMGLPSTTVP 3170 SPGLPTSGLP 3180 NKPSSASLSS 3190 PTPAQATMAM 3200 GPQQPPQQQQ 3210 QQQQPQVQQP 3220 PPPPAAQPPP 3230 TPQLPLQQQQ 3240 QRKDKDSEKV 3250 KEKEKAHKGK 3260 GEPLPVPKKE 3270 KGEAPTATAA 3280 TISAPLPTME 3290 YAVDPAQLQA 3300 LQAALTSDPT 3310 ALLTSQFLPY 3320 FVPGFSPYYA 3330 PQIPGALQSG 3340 YLQPMYGMEG 3350 LFPYSPALSQ 3360 ALMGLSPGSL 3370 LQQYQQYQQS 3380 LQEAIQQQQQ 3390 RQLQQQQQQK 3400 VQQQQPKASQ 3410 TPVPPGAPSP 3420 DKDPAKESPK 3430 PEEQKNTPRE 3440 VSPLLPKLPE 3450 EPEAESKSAD 3460 SLYDPFIVPK 3470 VQYKLVCRKC 3480 QAGFSDEEAA 3490 RSHLKSLCFF 3500 GQSVVNLQEM 3510 VLHVPTGGGG 3520 GGSGGGGGGG 3530 GGGGGGGSYH 3540 CLACESALCG 3550 EEALSQHLES 3560 ALHKHRTITR 3570 AARNAKEHPS 3580 LLPHSACFPD 3590 PSTASTSQSA 3600 AHSNDSPPPP 3610 SAAAPSSASP 3620 HASRKSWPQV 3630 VSRASAAKPP 3640 SFPPLSSSST 3650 VTSSSCSTSG 3660 VQPSMPTDDY 3670 SEESDTDLSQ 3680 KSDGPASPVE 3690 GPKDPSCPKD 3700 SGLTSVGTDT FRL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0007517 muscle organ development
Biological Process GO:0045662 negative regulation of myoblast differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045663 positive regulation of myoblast differentiation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:1904059 regulation of locomotor rhythm
Biological Process GO:0045664 regulation of neuron differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0071559 response to transforming growth factor beta
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003700 DNA-binding transcription factor activity

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.