Search Results

Overview

Uniprot IDQ15942
Protein NameZyxin
Gene NameZYX
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
184 VATPFSSKSSTKPAA
188 FSSKSSTKPAAGGTA
25 AFYAPQKKFGPVVAP
265 SSPAPAPKFSPVTPK
272 KFSPVTPKFTPVASK
279 KFTPVASKFSPGAPG
328 EKPRVQEKQHPVPPP
33 FGPVVAPKPKVNPFR
35 PVVAPKPKVNPFRPG

Function

Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)

Protein Sequence

10 MAAPRPSPAI 20 SVSVSAPAFY 30 APQKKFGPVV 40 APKPKVNPFR 50 PGDSEPPPAP 60 GAQRAQMGRV 70 GEIPPPPPED 80 FPLPPPPLAG 90 DGDDAEGALG 100 GAFPPPPPPI 110 EESFPPAPLE 120 EEIFPSPPPP 130 PEEEGGPEAP 140 IPPPPQPREK 150 VSSIDLEIDS 160 LSSLLDDMTK 170 NDPFKARVSS 180 GYVPPPVATP 190 FSSKSSTKPA 200 AGGTAPLPPW 210 KSPSSSQPLP 220 QVPAPAQSQT 230 QFHVQPQPQP 240 KPQVQLHVQS 250 QTQPVSLANT 260 QPRGPPASSP 270 APAPKFSPVT 280 PKFTPVASKF 290 SPGAPGGSGS 300 QPNQKLGHPE 310 ALSAGTGSPQ 320 PPSFTYAQQR 330 EKPRVQEKQH 340 PVPPPAQNQN 350 QVRSPGAPGP 360 LTLKEVEELE 370 QLTQQLMQDM 380 EHPQRQNVAV 390 NELCGRCHQP 400 LARAQPAVRA 410 LGQLFHIACF 420 TCHQCAQQLQ 430 GQQFYSLEGA 440 PYCEGCYTDT 450 LEKCNTCGEP 460 ITDRMLRATG 470 KAYHPHCFTC 480 VVCARPLEGT 490 SFIVDQANRP 500 HCVPDYHKQY 510 APRCSVCSEP 520 IMPEPGRDET 530 VRVVALDKNF 540 HMKCYKCEDC 550 GKPLSIEADD 560 NGCFPLDGHV 570 LCRKCHTARA QT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0043149 stress fiber assembly
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.