Search Results
Overview
| Uniprot ID | Q16134 |
|---|---|
| Protein Name | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial |
| Gene Name | ETFDH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | KELFPDWKEKGAPLN |
| 134 | LFPDWKEKGAPLNTP |
| 223 | TNDVGIQKDGAPKAT |
| 357 | RPTLEGGKRIAYGAR |
| 88 | LSAAVRLKQLAVAHE |
| 96 | QLAVAHEKDIRVCLV |
Function
Links fatty acid beta-oxidation and amino acid catabolism to the respiratory chain by transferring electrons from the electron transfer flavoprotein (ETF) to ubiquinone
Protein Sequence
10
MLVPLAKLSC
20
LAYQCFHALK
30
IKKNYLPLCA
40
TRWSSTSTVP
50
RITTHYTIYP
60
RDKDKRWEGV
70
NMERFAEEAD
80
VVIVGAGPAG
90
LSAAVRLKQL
100
AVAHEKDIRV
110
CLVEKAAQIG
120
AHTLSGACLD
130
PGAFKELFPD
140
WKEKGAPLNT
150
PVTEDRFGIL
160
TEKYRIPVPI
170
LPGLPMNNHG
180
NYIVRLGHLV
190
SWMGEQAEAL
200
GVEVYPGYAA
210
AEVLFHDDGS
220
VKGIATNDVG
230
IQKDGAPKAT
240
FERGLELHAK
250
VTIFAEGCHG
260
HLAKQLYKKF
270
DLRANCEPQT
280
YGIGLKELWV
290
IDEKNWKPGR
300
VDHTVGWPLD
310
RHTYGGSFLY
320
HLNEGEPLVA
330
LGLVVGLDYQ
340
NPYLSPFREF
350
QRWKHHPSIR
360
PTLEGGKRIA
370
YGARALNEGG
380
FQSIPKLTFP
390
GGLLIGCSPG
400
FMNVPKIKGT
410
HTAMKSGILA
420
AESIFNQLTS
430
ENLQSKTIGL
440
HVTEYEDNLK
450
NSWVWKELYS
460
VRNIRPSCHG
470
VLGVYGGMIY
480
TGIFYWILRG
490
MEPWTLKHKG
500
SDFERLKPAK
510
DCTPIEYPKP
520
DGQISFDLLS
530
SVALSGTNHE
540
HDQPAHLTLR
550
DDSIPVNRNL
560
SIYDGPEQRF
570
CPAGVYEFVP
580
VEQGDGFRLQ
590
INAQNCVHCK
600
TCDIKDPSQN
610
INWVVPEGGG
GPAYNGM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Molecular Function | GO:0048038 | quinone binding |
| Molecular Function | GO:0048039 | ubiquinone binding |
| Biological Process | GO:0022900 | electron transport chain |
| Biological Process | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| Biological Process | GO:0022904 | respiratory electron transport chain |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.