Search Results
Overview
| Uniprot ID | Q16143 |
|---|---|
| Protein Name | Beta-synuclein |
| Gene Name | SNCB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 12 | MKGLSMAKEGVVAAA |
| 23 | VAAAEKTKQGVTEAA |
| 34 | TEAAEKTKEGVLYVG |
| 43 | GVLYVGSKTREGVVQ |
| 58 | GVASVAEKTKEQASH |
| 60 | ASVAEKTKEQASHLG |
| 85 | AAATGLVKREEFPTD |
Function
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016234 | inclusion body |
| Cellular Component | GO:0043025 | neuronal cell body |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:1903136 | cuprous ion binding |
| Molecular Function | GO:0004859 | phospholipase inhibitor activity |
| Molecular Function | GO:0046914 | transition metal ion binding |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.