Search Results

Overview

Uniprot IDQ16181
Protein NameSeptin-7
Gene NameSEPTIN7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
208 PEECQQFKKQIMKEI
219 MKEIQEHKIKIYEFP
221 EIQEHKIKIYEFPET
235 TDDEEENKLVKKIKD
326 YNGVDNNKNKGQLTK
333 KNKGQLTKSPLAQME
366 QVFEMKVKEKVQKLK
373 KEKVQKLKDSEAELQ
89 GPSHRIKKTVQVEQS
97 TVQVEQSKVLIKEGG

Function

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830)

Protein Sequence

10 MSVSARSAAA 20 EERSVNSSTM 30 VAQQKNLEGY 40 VGFANLPNQV 50 YRKSVKRGFE 60 FTLMVVGESG 70 LGKSTLINSL 80 FLTDLYSPEY 90 PGPSHRIKKT 100 VQVEQSKVLI 110 KEGGVQLLLT 120 IVDTPGFGDA 130 VDNSNCWQPV 140 IDYIDSKFED 150 YLNAESRVNR 160 RQMPDNRVQC 170 CLYFIAPSGH 180 GLKPLDIEFM 190 KRLHEKVNII 200 PLIAKADTLT 210 PEECQQFKKQ 220 IMKEIQEHKI 230 KIYEFPETDD 240 EEENKLVKKI 250 KDRLPLAVVG 260 SNTIIEVNGK 270 RVRGRQYPWG 280 VAEVENGEHC 290 DFTILRNMLI 300 RTHMQDLKDV 310 TNNVHYENYR 320 SRKLAAVTYN 330 GVDNNKNKGQ 340 LTKSPLAQME 350 EERREHVAKM 360 KKMEMEMEQV 370 FEMKVKEKVQ 380 KLKDSEAELQ 390 RRHEQMKKNL 400 EAQHKELEEK 410 RRQFEDEKAN 420 WEAQQRILEQ 430 QNSSRTLEKN KKKGKIF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005930 axoneme
Cellular Component GO:0032153 cell division site
Cellular Component GO:0005929 cilium
Cellular Component GO:0032154 cleavage furrow
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0030496 midbody
Cellular Component GO:0097730 non-motile cilium
Cellular Component GO:0005634 nucleus
Cellular Component GO:0031105 septin complex
Cellular Component GO:0005940 septin ring
Cellular Component GO:0097227 sperm annulus
Cellular Component GO:0005819 spindle
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0060271 cilium assembly
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0061640 cytoskeleton-dependent cytokinesis
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:1902857 positive regulation of non-motile cilium assembly
Biological Process GO:0016476 regulation of embryonic cell shape
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.