Search Results

Overview

Uniprot IDQ16204
Protein NameCoiled-coil domain-containing protein 6
Gene NameCCDC6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
119 ISNTLFKKIQALQKE
148 LTNELSRKLMQLQHE
71 ASLQQENKVLKIELE

Function

No function data available.

Protein Sequence

10 MADSASESDT 20 DGAGGNSSSS 30 AAMQSSCSST 40 SGGGGGGGGG 50 GGGGKSGGIV 60 ISPFRLEELT 70 NRLASLQQEN 80 KVLKIELETY 90 KLKCKALQEE 100 NRDLRKASVT 110 IQARAEQEEE 120 FISNTLFKKI 130 QALQKEKETL 140 AVNYEKEEEF 150 LTNELSRKLM 160 QLQHEKAELE 170 QHLEQEQEFQ 180 VNKLMKKIKK 190 LENDTISKQL 200 TLEQLRREKI 210 DLENTLEQEQ 220 EALVNRLWKR 230 MDKLEAEKRI 240 LQEKLDQPVS 250 APPSPRDISM 260 EIDSPENMMR 270 HIRFLKNEVE 280 RLKKQLRAAQ 290 LQHSEKMAQY 300 LEEERHMREE 310 NLRLQRKLQR 320 EMERREALCR 330 QLSESESSLE 340 MDDERYFNEM 350 SAQGLRPRTV 360 SSPIPYTPSP 370 SSSRPISPGL 380 SYASHTVGFT 390 PPTSLTRAGM 400 SYYNSPGLHV 410 QHMGTSHGIT 420 RPSPRRSNSP 430 DKFKRPTPPP 440 SPNTQTPVQP 450 PPPPPPPPMQ 460 PTVPSAATSQ 470 PTPSQHSAHP SSQP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0017124 SH3 domain binding
Molecular Function GO:0005200 structural constituent of cytoskeleton

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.