Overview
| Uniprot ID | Q16222 |
|---|
| Protein Name | UDP-N-acetylhexosamine pyrophosphorylase |
|---|
| Gene Name | UAP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 145 |
IQAERILKLQQVAEK |
| 152 |
KLQQVAEKYYGNKCI |
| 182 |
KEFFTKHKYFGLKKE |
| 215 |
IILEEKNKVSMAPDG |
| 278 |
KGADCGAKVVEKTNP |
| 356 |
LQHHVAQKKIPYVDT |
| 357 |
QHHVAQKKIPYVDTQ |
Function
Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579)
Protein Sequence
10
MNINDLKLTL
20
SKAGQEHLLR
30
FWNELEEAQQ
40
VELYAELQAM
50
NFEELNFFFQ
60
KAIEGFNQSS
70
HQKNVDARME
80
PVPREVLGSA
90
TRDQDQLQAW
100
ESEGLFQISQ
110
NKVAVLLLAG
120
GQGTRLGVAY
130
PKGMYDVGLP
140
SRKTLFQIQA
150
ERILKLQQVA
160
EKYYGNKCII
170
PWYIMTSGRT
180
MESTKEFFTK
190
HKYFGLKKEN
200
VIFFQQGMLP
210
AMSFDGKIIL
220
EEKNKVSMAP
230
DGNGGLYRAL
240
AAQNIVEDME
250
QRGIWSIHVY
260
CVDNILVKVA
270
DPRFIGFCIQ
280
KGADCGAKVV
290
EKTNPTEPVG
300
VVCRVDGVYQ
310
VVEYSEISLA
320
TAQKRSSDGR
330
LLFNAGNIAN
340
HFFTVPFLRD
350
VVNVYEPQLQ
360
HHVAQKKIPY
370
VDTQGQLIKP
380
DKPNGIKMEK
390
FVFDIFQFAK
400
KFVVYEVLRE
410
DEFSPLKNAD
420
SQNGKDNPTT
430
ARHALMSLHH
440
CWVLNAGGHF
450
IDENGSRLPA
460
IPRSATNGKS
470
ETITADVNHN
480
LKDANDVPIQ
490
CEISPLISYA
500
GEGLESYVAD
510
KEFHAPLIID
520
ENGVHELVKN
GI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0141090 |
protein serine pyrophosphorylase activity |
| Molecular Function |
GO:0052630 |
UDP-N-acetylgalactosamine diphosphorylase activity |
| Molecular Function |
GO:0003977 |
UDP-N-acetylglucosamine diphosphorylase activity |
| Biological Process |
GO:0140374 |
antiviral innate immune response |
| Biological Process |
GO:0032481 |
positive regulation of type I interferon production |
| Biological Process |
GO:0006048 |
UDP-N-acetylglucosamine biosynthetic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.