Search Results
Overview
| Uniprot ID | Q16270 |
|---|---|
| Protein Name | Insulin-like growth factor-binding protein 7 |
| Gene Name | IGFBP7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 153 | KAITQVSKGTCEQGP |
| 275 | ALHEIPVKKGEGAEL |
| 97 | SRKRRKGKAGAAAGG |
Function
Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180)
Protein Sequence
10
MERPSLRALL
20
LGAAGLLLLL
30
LPLSSSSSSD
40
TCGPCEPASC
50
PPLPPLGCLL
60
GETRDACGCC
70
PMCARGEGEP
80
CGGGGAGRGY
90
CAPGMECVKS
100
RKRRKGKAGA
110
AAGGPGVSGV
120
CVCKSRYPVC
130
GSDGTTYPSG
140
CQLRAASQRA
150
ESRGEKAITQ
160
VSKGTCEQGP
170
SIVTPPKDIW
180
NVTGAQVYLS
190
CEVIGIPTPV
200
LIWNKVKRGH
210
YGVQRTELLP
220
GDRDNLAIQT
230
RGGPEKHEVT
240
GWVLVSPLSK
250
EDAGEYECHA
260
SNSQGQASAS
270
AKITVVDALH
280
EIPVKKGEGA
EL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005520 | insulin-like growth factor binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0071380 | cellular response to prostaglandin E stimulus |
| Biological Process | GO:0007566 | embryo implantation |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0001558 | regulation of cell growth |
| Biological Process | GO:0009966 | regulation of signal transduction |
| Biological Process | GO:0050810 | regulation of steroid biosynthetic process |
| Biological Process | GO:0051414 | response to cortisol |
| Biological Process | GO:0032526 | response to retinoic acid |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.