Overview
| Uniprot ID | Q16348 |
|---|
| Protein Name | Solute carrier family 15 member 2 |
|---|
| Gene Name | SLC15A2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 257 |
NIVAQVFKCIWFAIS |
Function
Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:16434549, PubMed:18367661, PubMed:7756356). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate (PubMed:7756356). Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed:16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:20406817)
Protein Sequence
10
MNPFQKNESK
20
ETLFSPVSIE
30
EVPPRPPSPP
40
KKPSPTICGS
50
NYPLSIAFIV
60
VNEFCERFSY
70
YGMKAVLILY
80
FLYFLHWNED
90
TSTSIYHAFS
100
SLCYFTPILG
110
AAIADSWLGK
120
FKTIIYLSLV
130
YVLGHVIKSL
140
GALPILGGQV
150
VHTVLSLIGL
160
SLIALGTGGI
170
KPCVAAFGGD
180
QFEEKHAEER
190
TRYFSVFYLS
200
INAGSLISTF
210
ITPMLRGDVQ
220
CFGEDCYALA
230
FGVPGLLMVI
240
ALVVFAMGSK
250
IYNKPPPEGN
260
IVAQVFKCIW
270
FAISNRFKNR
280
SGDIPKRQHW
290
LDWAAEKYPK
300
QLIMDVKALT
310
RVLFLYIPLP
320
MFWALLDQQG
330
SRWTLQAIRM
340
NRNLGFFVLQ
350
PDQMQVLNPL
360
LVLIFIPLFD
370
FVIYRLVSKC
380
GINFSSLRKM
390
AVGMILACLA
400
FAVAAAVEIK
410
INEMAPAQPG
420
PQEVFLQVLN
430
LADDEVKVTV
440
VGNENNSLLI
450
ESIKSFQKTP
460
HYSKLHLKTK
470
SQDFHFHLKY
480
HNLSLYTEHS
490
VQEKNWYSLV
500
IREDGNSISS
510
MMVKDTESRT
520
TNGMTTVRFV
530
NTLHKDVNIS
540
LSTDTSLNVG
550
EDYGVSAYRT
560
VQRGEYPAVH
570
CRTEDKNFSL
580
NLGLLDFGAA
590
YLFVITNNTN
600
QGLQAWKIED
610
IPANKMSIAW
620
QLPQYALVTA
630
GEVMFSVTGL
640
EFSYSQAPSS
650
MKSVLQAAWL
660
LTIAVGNIIV
670
LVVAQFSGLV
680
QWAEFILFSC
690
LLLVICLIFS
700
IMGYYYVPVK
710
TEDMRGPADK
720
HIPHIQGNMI
KLETKKTKL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0030670 |
phagocytic vesicle membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0071916 |
dipeptide transmembrane transporter activity |
| Molecular Function |
GO:0015333 |
peptide:proton symporter activity |
| Molecular Function |
GO:0042937 |
tripeptide transmembrane transporter activity |
| Biological Process |
GO:0140367 |
antibacterial innate immune response |
| Biological Process |
GO:0140206 |
dipeptide import across plasma membrane |
| Biological Process |
GO:0042938 |
dipeptide transport |
| Biological Process |
GO:0015835 |
peptidoglycan transport |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0070424 |
regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
| Biological Process |
GO:0070293 |
renal absorption |
| Biological Process |
GO:0150104 |
transport across blood-brain barrier |
| Biological Process |
GO:0140207 |
tripeptide import across plasma membrane |
| Biological Process |
GO:1990961 |
xenobiotic detoxification by transmembrane export across the plasma membrane |
| Biological Process |
GO:0042908 |
xenobiotic transport |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.