Search Results
Overview
| Uniprot ID | Q16352 |
|---|---|
| Protein Name | Alpha-internexin |
| Gene Name | INA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | RFAVFIEKVHQLETQ |
| 17 | CSSSSYRKVFGDGSR |
| 216 | ARLDLEKKVESLLDE |
| 278 | QYESLAAKNLQSAEE |
| 288 | QSAEEWYKSKFANLN |
| 290 | AEEWYKSKFANLNEQ |
| 447 | SSTGLSLKKEEEEEE |
| 482 | EETVISTKKTEKSNI |
| 486 | ISTKKTEKSNIEETT |
| 498 | ETTISSQKI****** |
| 88 | AARTNEYKIIRTNEK |
Function
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity)
Protein Sequence
10
MSFGSEHYLC
20
SSSSYRKVFG
30
DGSRLSARLS
40
GAGGAGGFRS
50
QSLSRSNVAS
60
SAACSSASSL
70
GLGLAYRRPP
80
ASDGLDLSQA
90
AARTNEYKII
100
RTNEKEQLQG
110
LNDRFAVFIE
120
KVHQLETQNR
130
ALEAELAALR
140
QRHAEPSRVG
150
ELFQRELRDL
160
RAQLEEASSA
170
RSQALLERDG
180
LAEEVQRLRA
190
RCEEESRGRE
200
GAERALKAQQ
210
RDVDGATLAR
220
LDLEKKVESL
230
LDELAFVRQV
240
HDEEVAELLA
250
TLQASSQAAA
260
EVDVTVAKPD
270
LTSALREIRA
280
QYESLAAKNL
290
QSAEEWYKSK
300
FANLNEQAAR
310
STEAIRASRE
320
EIHEYRRQLQ
330
ARTIEIEGLR
340
GANESLERQI
350
LELEERHSAE
360
VAGYQDSIGQ
370
LENDLRNTKS
380
EMARHLREYQ
390
DLLNVKMALD
400
IEIAAYRKLL
410
EGEETRFSTS
420
GLSISGLNPL
430
PNPSYLLPPR
440
ILSATTSKVS
450
STGLSLKKEE
460
EEEEASKVAS
470
KKTSQIGESF
480
EEILEETVIS
490
TKKTEKSNIE
ETTISSQKI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0005883 | neurofilament |
| Cellular Component | GO:0099160 | postsynaptic intermediate filament cytoskeleton |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0099184 | structural constituent of postsynaptic intermediate filament cytoskeleton |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0099170 | postsynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0021762 | substantia nigra development |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.