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Overview

Uniprot IDQ16363
Protein NameLaminin subunit alpha-4
Gene NameLAMA4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1159 VVDRRHVKSMDNEKM

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components

Protein Sequence

10 MALSSAWRSV 20 LPLWLLWSAA 30 CSRAASGDDN 40 AFPFDIEGSS 50 AVGRQDPPET 60 SEPRVALGRL 70 PPAAEKCNAG 80 FFHTLSGECV 90 PCDCNGNSNE 100 CLDGSGYCVH 110 CQRNTTGEHC 120 EKCLDGYIGD 130 SIRGAPQFCQ 140 PCPCPLPHLA 150 NFAESCYRKN 160 GAVRCICNEN 170 YAGPNCERCA 180 PGYYGNPLLI 190 GSTCKKCDCS 200 GNSDPNLIFE 210 DCDEVTGQCR 220 NCLRNTTGFK 230 CERCAPGYYG 240 DARIAKNCAV 250 CNCGGGPCDS 260 VTGECLEEGF 270 EPPTGMDCPT 280 ISCDKCVWDL 290 TDDLRLAALS 300 IEEGKSGVLS 310 VSSGAAAHRH 320 VNEINATIYL 330 LKTKLSEREN 340 QYALRKIQIN 350 NAENTMKSLL 360 SDVEELVEKE 370 NQASRKGQLV 380 QKESMDTINH 390 ASQLVEQAHD 400 MRDKIQEINN 410 KMLYYGEEHE 420 LSPKEISEKL 430 VLAQKMLEEI 440 RSRQPFFTQR 450 ELVDEEADEA 460 YELLSQAESW 470 QRLHNETRTL 480 FPVVLEQLDD 490 YNAKLSDLQE 500 ALDQALNYVR 510 DAEDMNRATA 520 ARQRDHEKQQ 530 ERVREQMEVV 540 NMSLSTSADS 550 LTTPRLTLSE 560 LDDIIKNASG 570 IYAEIDGAKS 580 ELQVKLSNLS 590 NLSHDLVQEA 600 IDHAQDLQQE 610 ANELSRKLHS 620 SDMNGLVQKA 630 LDASNVYENI 640 VNYVSEANET 650 AEFALNTTDR 660 IYDAVSGIDT 670 QIIYHKDESE 680 NLLNQARELQ 690 AKAESSSDEA 700 VADTSRRVGG 710 ALARKSALKT 720 RLSDAVKQLQ 730 AAERGDAQQR 740 LGQSRLITEE 750 ANRTTMEVQQ 760 ATAPMANNLT 770 NWSQNLQHFD 780 SSAYNTAVNS 790 ARDAVRNLTE 800 VVPQLLDQLR 810 TVEQKRPASN 820 VSASIQRIRE 830 LIAQTRSVAS 840 KIQVSMMFDG 850 QSAVEVHSRT 860 SMDDLKAFTS 870 LSLYMKPPVK 880 RPELTETADQ 890 FILYLGSKNA 900 KKEYMGLAIK 910 NDNLVYVYNL 920 GTKDVEIPLD 930 SKPVSSWPAY 940 FSIVKIERVG 950 KHGKVFLTVP 960 SLSSTAEEKF 970 IKKGEFSGDD 980 SLLDLDPEDT 990 VFYVGGVPSN 1000 FKLPTSLNLP 1010 GFVGCLELAT 1020 LNNDVISLYN 1030 FKHIYNMDPS 1040 TSVPCARDKL 1050 AFTQSRAASY 1060 FFDGSGYAVV 1070 RDITRRGKFG 1080 QVTRFDIEVR 1090 TPADNGLILL 1100 MVNGSMFFRL 1110 EMRNGYLHVF 1120 YDFGFSGGPV 1130 HLEDTLKKAQ 1140 INDAKYHEIS 1150 IIYHNDKKMI 1160 LVVDRRHVKS 1170 MDNEKMKIPF 1180 TDIYIGGAPP 1190 EILQSRALRA 1200 HLPLDINFRG 1210 CMKGFQFQKK 1220 DFNLLEQTET 1230 LGVGYGCPED 1240 SLISRRAYFN 1250 GQSFIASIQK 1260 ISFFDGFEGG 1270 FNFRTLQPNG 1280 LLFYYASGSD 1290 VFSISLDNGT 1300 VIMDVKGIKV 1310 QSVDKQYNDG 1320 LSHFVISSVS 1330 PTRYELIVDK 1340 SRVGSKNPTK 1350 GKIEQTQASE 1360 KKFYFGGSPI 1370 SAQYANFTGC 1380 ISNAYFTRVD 1390 RDVEVEDFQR 1400 YTEKVHTSLY 1410 ECPIESSPLF 1420 LLHKKGKNLS 1430 KPKASQNKKG 1440 GKSKDAPSWD 1450 PVALKLPERN 1460 TPRNSHCHLS 1470 NSPRAIEHAY 1480 QYGGTANSRQ 1490 EFEHLKGDFG 1500 AKSQFSIRLR 1510 TRSSHGMIFY 1520 VSDQEENDFM 1530 TLFLAHGRLV 1540 YMFNVGHKKL 1550 KIRSQEKYND 1560 GLWHDVIFIR 1570 ERSSGRLVID 1580 GLRVLEESLP 1590 PTEATWKIKG 1600 PIYLGGVAPG 1610 KAVKNVQINS 1620 IYSFSGCLSN 1630 LQLNGASITS 1640 ASQTFSVTPC 1650 FEGPMETGTY 1660 FSTEGGYVVL 1670 DESFNIGLKF 1680 EIAFEVRPRS 1690 SSGTLVHGHS 1700 VNGEYLNVHM 1710 KNGQVIVKVN 1720 NGIRDFSTSV 1730 TPKQSLCDGR 1740 WHRITVIRDS 1750 NVVQLDVDSE 1760 VNHVVGPLNP 1770 KPIDHREPVF 1780 VGGVPESLLT 1790 PRLAPSKPFT 1800 GCIRHFVIDG 1810 HPVSFSKAAL 1820 VSGAVSINSC PAA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043258 laminin-421 trimer
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0043257 laminin-411 trimer
Cellular Component GO:1990338 laminin-423 trimer
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0007399 nervous system development
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0007165 signal transduction

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.