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Overview

Uniprot ID	Q16401
Protein Name	26S proteasome non-ATPase regulatory subunit 5
Gene Name	PSMD5
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
147	SVAKAAIKSLSRISL
358	KNAPVELKIRCLDAI

Function

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5

Protein Sequence

10 MAAQALALLR 20 EVARLEAPLE 30 ELRALHSVLQ 40 AVPLNELRQQ 50 AAELRLGPLF 60 SLLNENHREK 70 TTLCVSILER 80 LLQAMEPVHV 90 ARNLRVDLQR 100 GLIHPDDSVK 110 ILTLSQIGRI 120 VENSDAVTEI 130 LNNAELLKQI 140 VYCIGGENLS 150 VAKAAIKSLS 160 RISLTQAGLE 170 ALFESNLLDD 180 LKSVMKTNDI 190 VRYRVYELII 200 EISSVSPESL 210 NYCTTSGLVT 220 QLLRELTGED 230 VLVRATCIEM 240 VTSLAYTHHG 250 RQYLAQEGVI 260 DQISNIIVGA 270 DSDPFSSFYL 280 PGFVKFFGNL 290 AVMDSPQQIC 300 ERYPIFVEKV 310 FEMIESQDPT 320 MIGVAVDTVG 330 ILGSNVEGKQ 340 VLQKTGTRFE 350 RLLMRIGHQS 360 KNAPVELKIR 370 CLDAISSLLY 380 LPPEQQTDDL 390 LRMTESWFSS 400 LSRDPLELFR 410 GISSQPFPEL 420 HCAALKVFTA 430 IANQPWAQKL 440 MFNSPGFVEY 450 VVDRSVEHDK 460 ASKDAKYELV 470 KALANSKTIA 480 EIFGNPNYLR 490 LRTYLSEGPY 500 YVKPVSTTAV EGAE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0022624	proteasome accessory complex
Cellular Component	GO:0000502	proteasome complex
Biological Process	GO:0070682	proteasome regulatory particle assembly

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.