Search Results

Overview

Uniprot ID	Q16527
Protein Name	Cysteine and glycine-rich protein 2
Gene Name	CSRP2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
108	TTNPNTSKFAQKYGG
112	NTSKFAQKYGGAEKC
173	YCKGCYAKNFGPKGF
178	YAKNFGPKGFGYGQG

Function

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system

Protein Sequence

10 MPVWGGGNKC 20 GACGRTVYHA 30 EEVQCDGRSF 40 HRCCFLCMVC 50 RKNLDSTTVA 60 IHDEEIYCKS 70 CYGKKYGPKG 80 YGYGQGAGTL 90 NMDRGERLGI 100 KPESVQPHRP 110 TTNPNTSKFA 120 QKYGGAEKCS 130 RCGDSVYAAE 140 KIIGAGKPWH 150 KNCFRCAKCG 160 KSLESTTLTE 170 KEGEIYCKGC 180 YAKNFGPKGF 190 GYGQGAGALV HAQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0030018	Z disc
Molecular Function	GO:0042805	actinin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0008307	structural constituent of muscle
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0060537	muscle tissue development
Biological Process	GO:0045214	sarcomere organization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.