Search Results

Overview

Uniprot IDQ16555
Protein NameDihydropyrimidinase-related protein 2
Gene NameDPYSL2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
20 TSDRLLIKGGKIVND
258 YITKVMSKSSAEVIA
270 VIAQARKKGTVVYGE
293 DGSHYWSKNWAKAAA
345 TAQKAVGKDNFTLIP
368 RMSVIWDKAVVTGKM
472 SGRYIPRKPFPDFVY
511 CEVSVTPKTVTPASS
520 VTPASSAKTSPAKQQ
525 SAKTSPAKQQAPPVR
56 LIVPGGVKTIEAHSR
6 **MSYQGKKNIPRIT

Function

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis

Protein Sequence

10 MSYQGKKNIP 20 RITSDRLLIK 30 GGKIVNDDQS 40 FYADIYMEDG 50 LIKQIGENLI 60 VPGGVKTIEA 70 HSRMVIPGGI 80 DVHTRFQMPD 90 QGMTSADDFF 100 QGTKAALAGG 110 TTMIIDHVVP 120 EPGTSLLAAF 130 DQWREWADSK 140 SCCDYSLHVD 150 ISEWHKGIQE 160 EMEALVKDHG 170 VNSFLVYMAF 180 KDRFQLTDCQ 190 IYEVLSVIRD 200 IGAIAQVHAE 210 NGDIIAEEQQ 220 RILDLGITGP 230 EGHVLSRPEE 240 VEAEAVNRAI 250 TIANQTNCPL 260 YITKVMSKSS 270 AEVIAQARKK 280 GTVVYGEPIT 290 ASLGTDGSHY 300 WSKNWAKAAA 310 FVTSPPLSPD 320 PTTPDFLNSL 330 LSCGDLQVTG 340 SAHCTFNTAQ 350 KAVGKDNFTL 360 IPEGTNGTEE 370 RMSVIWDKAV 380 VTGKMDENQF 390 VAVTSTNAAK 400 VFNLYPRKGR 410 IAVGSDADLV 420 IWDPDSVKTI 430 SAKTHNSSLE 440 YNIFEGMECR 450 GSPLVVISQG 460 KIVLEDGTLH 470 VTEGSGRYIP 480 RKPFPDFVYK 490 RIKARSRLAE 500 LRGVPRGLYD 510 GPVCEVSVTP 520 KTVTPASSAK 530 TSPAKQQAPP 540 VRNLHQSGFS 550 LSGAQIDDNI 560 PRRTTQRIVA 570 PPGGRANITS LG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0045171 intercellular bridge
Cellular Component GO:0016020 membrane
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0072686 mitotic spindle
Cellular Component GO:0120025 plasma membrane bounded cell projection
Molecular Function GO:0004157 dihydropyrimidinase activity
Molecular Function GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0006897 endocytosis
Biological Process GO:0007399 nervous system development
Biological Process GO:0006139 nucleobase-containing compound metabolic process
Biological Process GO:0007165 signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.