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Overview

Uniprot IDQ16623
Protein NameSyntaxin-1A
Gene NameSTX1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
55 AENVEEVKRKHSAIL
83 EELMSDIKKTANKVR

Function

Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity)

Protein Sequence

10 MKDRTQELRT 20 AKDSDDDDDV 30 AVTVDRDRFM 40 DEFFEQVEEI 50 RGFIDKIAEN 60 VEEVKRKHSA 70 ILASPNPDEK 80 TKEELEELMS 90 DIKKTANKVR 100 SKLKSIEQSI 110 EQEEGLNRSS 120 ADLRIRKTQH 130 STLSRKFVEV 140 MSEYNATQSD 150 YRERCKGRIQ 160 RQLEITGRTT 170 TSEELEDMLE 180 SGNPAIFASG 190 IIMDSSISKQ 200 ALSEIETRHS 210 EIIKLENSIR 220 ELHDMFMDMA 230 MLVESQGEMI 240 DRIEYNVEHA 250 VDYVERAVSD 260 TKKAVKYQSK 270 ARRKKIMIII 280 CCVILGIVIA STVGGIFA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042641 actomyosin
Cellular Component GO:0030141 secretory granule
Cellular Component GO:0031201 SNARE complex
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
Cellular Component GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
Cellular Component GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
Cellular Component GO:0008076 voltage-gated potassium channel complex
Molecular Function GO:0043008 ATP-dependent protein binding
Molecular Function GO:0019855 calcium channel inhibitor activity
Molecular Function GO:0048306 calcium-dependent protein binding
Molecular Function GO:0019869 chloride channel inhibitor activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0032028 myosin head/neck binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0005484 SNAP receptor activity
Molecular Function GO:0000149 SNARE binding
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0006887 exocytosis
Biological Process GO:0030073 insulin secretion
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0045956 positive regulation of calcium ion-dependent exocytosis
Biological Process GO:0033605 positive regulation of catecholamine secretion
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Biological Process GO:0001956 positive regulation of neurotransmitter secretion
Biological Process GO:0010701 positive regulation of norepinephrine secretion
Biological Process GO:0072657 protein localization to membrane
Biological Process GO:0016925 protein sumoylation
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0010807 regulation of synaptic vesicle priming
Biological Process GO:0009629 response to gravity
Biological Process GO:0032940 secretion by cell
Cellular Component GO:0030424 axon
Cellular Component GO:0005829 cytosol
Cellular Component GO:0012505 endomembrane system
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098839 postsynaptic density membrane
Cellular Component GO:0048787 presynaptic active zone membrane
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Biological Process GO:0035493 SNARE complex assembly
Biological Process GO:0035494 SNARE complex disassembly
Biological Process GO:0016081 synaptic vesicle docking
Biological Process GO:0048488 synaptic vesicle endocytosis
Biological Process GO:0016079 synaptic vesicle exocytosis
Biological Process GO:0048278 vesicle docking
Biological Process GO:0006906 vesicle fusion

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.