Search Results
Overview
| Uniprot ID | Q16625 |
|---|---|
| Protein Name | Occludin |
| Gene Name | OCLN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 379 | GNFETPSKRAPAKGR |
Function
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions
Protein Sequence
10
MSSRPLESPP
20
PYRPDEFKPN
30
HYAPSNDIYG
40
GEMHVRPMLS
50
QPAYSFYPED
60
EILHFYKWTS
70
PPGVIRILSM
80
LIIVMCIAIF
90
ACVASTLAWD
100
RGYGTSLLGG
110
SVGYPYGGSG
120
FGSYGSGYGY
130
GYGYGYGYGG
140
YTDPRAAKGF
150
MLAMAAFCFI
160
AALVIFVTSV
170
IRSEMSRTRR
180
YYLSVIIVSA
190
ILGIMVFIAT
200
IVYIMGVNPT
210
AQSSGSLYGS
220
QIYALCNQFY
230
TPAATGLYVD
240
QYLYHYCVVD
250
PQEAIAIVLG
260
FMIIVAFALI
270
IFFAVKTRRK
280
MDRYDKSNIL
290
WDKEHIYDEQ
300
PPNVEEWVKN
310
VSAGTQDVPS
320
PPSDYVERVD
330
SPMAYSSNGK
340
VNDKRFYPES
350
SYKSTPVPEV
360
VQELPLTSPV
370
DDFRQPRYSS
380
GGNFETPSKR
390
APAKGRAGRS
400
KRTEQDHYET
410
DYTTGGESCD
420
ELEEDWIREY
430
PPITSDQQRQ
440
LYKRNFDTGL
450
QEYKSLQSEL
460
DEINKELSRL
470
DKELDDYREE
480
SEEYMAAADE
490
YNRLKQVKGS
500
ADYKSKKNHC
510
KQLKSKLSHI
520
KKMVGDYDRQ
KT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016327 | apicolateral plasma membrane |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0070160 | tight junction |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Biological Process | GO:0070830 | bicellular tight junction assembly |
| Biological Process | GO:0045216 | cell-cell junction organization |
| Biological Process | GO:0010631 | epithelial cell migration |
| Biological Process | GO:0035633 | maintenance of blood-brain barrier |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:1905605 | positive regulation of blood-brain barrier permeability |
| Biological Process | GO:0046326 | positive regulation of D-glucose import across plasma membrane |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0031116 | positive regulation of microtubule polymerization |
| Biological Process | GO:0090303 | positive regulation of wound healing |
| Biological Process | GO:1902463 | protein localization to cell leading edge |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0010827 | regulation of D-glucose transmembrane transport |
Reference
PMID: N/A