Search Results

Overview

Uniprot IDQ16629
Protein NameSerine/arginine-rich splicing factor 7
Gene NameSRSF7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
112 RCYECGEKGHYAYDC
24 NLGTGAGKGELERAF
70 AVRGLDGKVICGSRV

Function

Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific

Protein Sequence

10 MSRYGRYGGE 20 TKVYVGNLGT 30 GAGKGELERA 40 FSYYGPLRTV 50 WIARNPPGFA 60 FVEFEDPRDA 70 EDAVRGLDGK 80 VICGSRVRVE 90 LSTGMPRRSR 100 FDRPPARRPF 110 DPNDRCYECG 120 EKGHYAYDCH 130 RYSRRRRSRS 140 RSRSHSRSRG 150 RRYSRSRSRS 160 RGRRSRSASP 170 RRSRSISLRR 180 SRSASLRRSR 190 SGSIKGSRYF 200 QSPSRSRSRS 210 RSISRPRSSR 220 SKSRSPSPKR 230 SRSPSGSPRR SASPERMD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0051028 mRNA transport
Biological Process GO:0048025 negative regulation of mRNA splicing, via spliceosome
Biological Process GO:0000381 regulation of alternative mRNA splicing, via spliceosome
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.