Search Results

Overview

Uniprot ID	Q16643
Protein Name	Drebrin
Gene Name	DBN1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
173	TDAAVEMKRINREQF
238	QIEEHRRKQQTLEAE
252	EEAKRRLKEQSIFGD

Function

Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity)

Protein Sequence

10 MAGVSFSGHR 20 LELLAAYEEV 30 IREESAADWA 40 LYTYEDGSDD 50 LKLAASGEGG 60 LQELSGHFEN 70 QKVMYGFCSV 80 KDSQAALPKY 90 VLINWVGEDV 100 PDARKCACAS 110 HVAKVAEFFQ 120 GVDVIVNASS 130 VEDIDAGAIG 140 QRLSNGLARL 150 SSPVLHRLRL 160 REDENAEPVG 170 TTYQKTDAAV 180 EMKRINREQF 190 WEQAKKEEEL 200 RKEEERKKAL 210 DERLRFEQER 220 MEQERQEQEE 230 RERRYREREQ 240 QIEEHRRKQQ 250 TLEAEEAKRR 260 LKEQSIFGDH 270 RDEEEETHMK 280 KSESEVEEAA 290 AIIAQRPDNP 300 REFFKQQERV 310 ASASAGSCDV 320 PSPFNHRPGS 330 HLDSHRRMAP 340 TPIPTRSPSD 350 SSTASTPVAE 360 QIERALDEVT 370 SSQPPPLPPP 380 PPPAQETQEP 390 SPILDSEETR 400 AAAPQAWAGP 410 MEEPPQAQAP 420 PRGPGSPAED 430 LMFMESAEQA 440 VLAAPVEPAT 450 ADATEIHDAA 460 DTIETDTATA 470 DTTVANNVPP 480 AATSLIDLWP 490 GNGEGASTLQ 500 GEPRAPTPPS 510 GTEVTLAEVP 520 LLDEVAPEPL 530 LPAGEGCATL 540 LNFDELPEPP 550 ATFCDPEEVE 560 GESLAAPQTP 570 TLPSALEELE 580 QEQEPEPHLL 590 TNGETTQKEG 600 TQASEGYFSQ 610 SQEEEFAQSE 620 ELCAKAPPPV 630 FYNKPPEIDI 640 TCWDADPVPE EEEGFEGGD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0030863	cortical cytoskeleton
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0005921	gap junction
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0099524	postsynaptic cytosol
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0045211	postsynaptic membrane
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0005522	profilin binding
Molecular Function	GO:0140311	protein sequestering activity
Biological Process	GO:0007015	actin filament organization
Biological Process	GO:0048699	generation of neurons
Biological Process	GO:0061351	neural precursor cell proliferation
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis
Biological Process	GO:1902685	positive regulation of receptor localization to synapse
Biological Process	GO:0031915	positive regulation of synaptic plasticity
Biological Process	GO:0050773	regulation of dendrite development
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.