Search Results

Overview

Uniprot IDQ16658
Protein NameFascin
Gene NameFSCN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
241 SGPSGTLKAGKATKV
247 LKAGKATKVGKDELF
399 HGFIGCRKVTGTLDA
41 NASASSLKKKQIWTL
42 ASASSLKKKQIWTLE
43 SASSLKKKQIWTLEQ
464 DYNKVAIKVGGRYLK
471 KVGGRYLKGDHAGVL
74 GRYLAADKDGNVTCE

Function

Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786)

Protein Sequence

10 MTANGTAEAV 20 QIQFGLINCG 30 NKYLTAEAFG 40 FKVNASASSL 50 KKKQIWTLEQ 60 PPDEAGSAAV 70 CLRSHLGRYL 80 AADKDGNVTC 90 EREVPGPDCR 100 FLIVAHDDGR 110 WSLQSEAHRR 120 YFGGTEDRLS 130 CFAQTVSPAE 140 KWSVHIAMHP 150 QVNIYSVTRK 160 RYAHLSARPA 170 DEIAVDRDVP 180 WGVDSLITLA 190 FQDQRYSVQT 200 ADHRFLRHDG 210 RLVARPEPAT 220 GYTLEFRSGK 230 VAFRDCEGRY 240 LAPSGPSGTL 250 KAGKATKVGK 260 DELFALEQSC 270 AQVVLQAANE 280 RNVSTRQGMD 290 LSANQDEETD 300 QETFQLEIDR 310 DTKKCAFRTH 320 TGKYWTLTAT 330 GGVQSTASSK 340 NASCYFDIEW 350 RDRRITLRAS 360 NGKFVTSKKN 370 GQLAASVETA 380 GDSELFLMKL 390 INRPIIVFRG 400 EHGFIGCRKV 410 TGTLDANRSS 420 YDVFQLEFND 430 GAYNIKDSTG 440 KYWTVGSDSA 450 VTSSGDTPVD 460 FFFEFCDYNK 470 VAIKVGGRYL 480 KGDHAGVLKA 490 SAETVDPASL WEY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0031253 cell projection membrane
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0030175 filopodium
Cellular Component GO:0030426 growth cone
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0044393 microspike
Cellular Component GO:0005902 microvillus
Cellular Component GO:0002102 podosome
Cellular Component GO:0001726 ruffle
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051017 actin filament bundle assembly
Biological Process GO:0016477 cell migration
Biological Process GO:0048870 cell motility
Biological Process GO:0007043 cell-cell junction assembly
Biological Process GO:0035089 establishment of apical/basal cell polarity
Biological Process GO:0007163 establishment or maintenance of cell polarity
Biological Process GO:0030035 microspike assembly
Biological Process GO:0030046 parallel actin filament bundle assembly
Biological Process GO:0090091 positive regulation of extracellular matrix disassembly
Biological Process GO:0051491 positive regulation of filopodium assembly
Biological Process GO:0010592 positive regulation of lamellipodium assembly
Biological Process GO:0071803 positive regulation of podosome assembly
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0032534 regulation of microvillus assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.