Search Results
Overview
| Uniprot ID | Q16695 |
|---|---|
| Protein Name | Histone H3.1t |
| Gene Name | H3-4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 15 | ARKSTGGKAPRKQLA |
| 28 | LATKVARKSAPATGG |
| 57 | REIRRYQKSTELLIR |
| 80 | REIAQDFKTDLRFQS |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Protein Sequence
10
MARTKQTARK
20
STGGKAPRKQ
30
LATKVARKSA
40
PATGGVKKPH
50
RYRPGTVALR
60
EIRRYQKSTE
70
LLIRKLPFQR
80
LMREIAQDFK
90
TDLRFQSSAV
100
MALQEACESY
110
LVGLFEDTNL
120
CVIHAKRVTI
130
MPKDIQLARR
IRGERA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0000794 | condensed nuclear chromosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0007284 | spermatogonial cell division |
Reference
PMID: N/A