Search Results

Overview

Uniprot IDQ16698
Protein Name2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
Gene NameDECR1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
110 ISSQTGNKVHAIQCD
185 EIGKQLIKAQKGAAF
222 AGVEAMSKSLAAEWG
230 SLAAEWGKYGMRFNV
244 VIQPGPIKTKGAFSR
246 QPGPIKTKGAFSRLD
260 DPTGTFEKEMIGRIP
319 NDLRKVTKEQWDTIE
49 KFFSPLQKAMLPPNS
73 GGGTGLGKGMTTLLS
97 SRKMDVLKATAEQIS

Function

Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids (Probable) (PubMed:15531764, PubMed:26474213). Together with the Enoyl-CoA delta isomerase 1 (ECI1) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:26474213). It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria (PubMed:15531764). Acts primarily on polyunsaturated fatty acids (Probable). Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA (PubMed:15531764). Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (Probable)

Protein Sequence

10 MKLPARVFFT 20 LGSRLPCGLA 30 PRRFFSYGTK 40 ILYQNTEALQ 50 SKFFSPLQKA 60 MLPPNSFQGK 70 VAFITGGGTG 80 LGKGMTTLLS 90 SLGAQCVIAS 100 RKMDVLKATA 110 EQISSQTGNK 120 VHAIQCDVRD 130 PDMVQNTVSE 140 LIKVAGHPNI 150 VINNAAGNFI 160 SPTERLSPNA 170 WKTITDIVLN 180 GTAFVTLEIG 190 KQLIKAQKGA 200 AFLSITTIYA 210 ETGSGFVVPS 220 ASAKAGVEAM 230 SKSLAAEWGK 240 YGMRFNVIQP 250 GPIKTKGAFS 260 RLDPTGTFEK 270 EMIGRIPCGR 280 LGTVEELANL 290 AAFLCSDYAS 300 WINGAVIKFD 310 GGEEVLISGE 320 FNDLRKVTKE 330 QWDTIEELIR KTKGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:1902494 catalytic complex
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0070402 NADPH binding
Biological Process GO:0006635 fatty acid beta-oxidation
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.