Search Results
Overview
| Uniprot ID | Q16718 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 |
| Gene Name | NDUFA5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 40 | DVLEEIPKNAAYRKY |
| 46 | PKNAAYRKYTEQITN |
| 7 | *MAGVLKKTTGLVGL |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Protein Sequence
10
MAGVLKKTTG
20
LVGLAVCNTP
30
HERLRILYTK
40
ILDVLEEIPK
50
NAAYRKYTEQ
60
ITNEKLAMVK
70
AEPDVKKLED
80
QLQGGQLEEV
90
ILQAEHELNL
100
ARKMREWKLW
110
EPLVEEPPAD
QWKWPI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
| Biological Process | GO:0022904 | respiratory electron transport chain |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.