Search Results

Overview

Uniprot IDQ16719
Protein NameKynureninase
Gene NameKYNU
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
21 QRIAAELKCHPTDER
384 GKDKAATKKPVVNII
427 KRGVVCDKRNPNGIR
84 GLQPKMVKTYLEEEL
93 YLEEELDKWAKIAAY

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity

Protein Sequence

10 MEPSSLELPA 20 DTVQRIAAEL 30 KCHPTDERVA 40 LHLDEEDKLR 50 HFRECFYIPK 60 IQDLPPVDLS 70 LVNKDENAIY 80 FLGNSLGLQP 90 KMVKTYLEEE 100 LDKWAKIAAY 110 GHEVGKRPWI 120 TGDESIVGLM 130 KDIVGANEKE 140 IALMNALTVN 150 LHLLMLSFFK 160 PTPKRYKILL 170 EAKAFPSDHY 180 AIESQLQLHG 190 LNIEESMRMI 200 KPREGEETLR 210 IEDILEVIEK 220 EGDSIAVILF 230 SGVHFYTGQH 240 FNIPAITKAG 250 QAKGCYVGFD 260 LAHAVGNVEL 270 YLHDWGVDFA 280 CWCSYKYLNA 290 GAGGIAGAFI 300 HEKHAHTIKP 310 ALVGWFGHEL 320 STRFKMDNKL 330 QLIPGVCGFR 340 ISNPPILLVC 350 SLHASLEIFK 360 QATMKALRKK 370 SVLLTGYLEY 380 LIKHNYGKDK 390 AATKKPVVNI 400 ITPSHVEERG 410 CQLTITFSVP 420 NKDVFQELEK 430 RGVVCDKRNP 440 NGIRVAPVPL 450 YNSFHDVYKF 460 TNLLTSILDS AETKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0030429 kynureninase activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan
Biological Process GO:0043420 anthranilate metabolic process
Biological Process GO:0097053 L-kynurenine catabolic process
Biological Process GO:0006569 L-tryptophan catabolic process
Biological Process GO:0019441 L-tryptophan catabolic process to L-kynurenine
Biological Process GO:0009435 NAD+ biosynthetic process
Biological Process GO:0019805 quinolinate biosynthetic process
Biological Process GO:0034341 response to type II interferon
Biological Process GO:0034516 response to vitamin B6

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.