Search Results

Overview

Uniprot ID	Q16720
Protein Name	Plasma membrane calcium-transporting ATPase 3
Gene Name	ATP2B3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
347	GEMEEREKKKANAPK
348	EMEEREKKKANAPKK
349	MEEREKKKANAPKKE
754	IEQERLDKVWPKLRV

Function

ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals (PubMed:18029012, PubMed:22912398, PubMed:25953895, PubMed:27035656). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:25953895, PubMed:27035656). May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (By similarity)

Protein Sequence

10 MGDMANSSIE 20 FHPKPQQQRD 30 VPQAGGFGCT 40 LAELRTLMEL 50 RGAEALQKIE 60 EAYGDVSGLC 70 RRLKTSPTEG 80 LADNTNDLEK 90 RRQIYGQNFI 100 PPKQPKTFLQ 110 LVWEALQDVT 120 LIILEVAAIV 130 SLGLSFYAPP 140 GEESEACGNV 150 SGGAEDEGEA 160 EAGWIEGAAI 170 LLSVICVVLV 180 TAFNDWSKEK 190 QFRGLQSRIE 200 QEQKFTVIRN 210 GQLLQVPVAA 220 LVVGDIAQVK 230 YGDLLPADGV 240 LIQANDLKID 250 ESSLTGESDH 260 VRKSADKDPM 270 LLSGTHVMEG 280 SGRMVVTAVG 290 VNSQTGIIFT 300 LLGAGGEEEE 310 KKDKKGKQQD 320 GAMESSQTKA 330 KKQDGAVAME 340 MQPLKSAEGG 350 EMEEREKKKA 360 NAPKKEKSVL 370 QGKLTKLAVQ 380 IGKAGLVMSA 390 ITVIILVLYF 400 VIETFVVEGR 410 TWLAECTPVY 420 VQYFVKFFII 430 GVTVLVVAVP 440 EGLPLAVTIS 450 LAYSVKKMMK 460 DNNLVRHLDA 470 CETMGNATAI 480 CSDKTGTLTT 490 NRMTVVQSYL 500 GDTHYKEIPA 510 PSALTPKILD 520 LLVHAISINS 530 AYTTKILPPE 540 KEGALPRQVG 550 NKTECALLGF 560 VLDLKRDFQP 570 VREQIPEDKL 580 YKVYTFNSVR 590 KSMSTVIRMP 600 DGGFRLFSKG 610 ASEILLKKCT 620 NILNSNGELR 630 GFRPRDRDDM 640 VRKIIEPMAC 650 DGLRTICIAY 660 RDFSAGQEPD 670 WDNENEVVGD 680 LTCIAVVGIE 690 DPVRPEVPEA 700 IRKCQRAGIT 710 VRMVTGDNIN 720 TARAIAAKCG 730 IIQPGEDFLC 740 LEGKEFNRRI 750 RNEKGEIEQE 760 RLDKVWPKLR 770 VLARSSPTDK 780 HTLVKGIIDS 790 TTGEQRQVVA 800 VTGDGTNDGP 810 ALKKADVGFA 820 MGIAGTDVAK 830 EASDIILTDD 840 NFTSIVKAVM 850 WGRNVYDSIS 860 KFLQFQLTVN 870 VVAVIVAFTG 880 ACITQDSPLK 890 AVQMLWVNLI 900 MDTFASLALA 910 TEPPTESLLL 920 RKPYGRDKPL 930 ISRTMMKNIL 940 GHAVYQLAII 950 FTLLFVGELF 960 FDIDSGRNAP 970 LHSPPSEHYT 980 IIFNTFVMMQ 990 LFNEINARKI 1000 HGERNVFDGI 1010 FSNPIFCTIV 1020 LGTFGIQIVI 1030 VQFGGKPFSC 1040 SPLSTEQWLW 1050 CLFVGVGELV 1060 WGQVIATIPT 1070 SQLKCLKEAG 1080 HGPGKDEMTD 1090 EELAEGEEEI 1100 DHAERELRRG 1110 QILWFRGLNR 1120 IQTQIRVVKA 1130 FRSSLYEGLE 1140 KPESKTSIHN 1150 FMATPEFLIN 1160 DYTHNIPLID 1170 DTDVDENEER 1180 LRAPPPPSPN 1190 QNNNAIDSGI 1200 YLTTHVTKSA 1210 TSSVFSSSPG 1220 SPLHSVETSL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:1903561	extracellular vesicle
Cellular Component	GO:0098982	GABA-ergic synapse
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:1990032	parallel fiber
Cellular Component	GO:0098688	parallel fiber to Purkinje cell synapse
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0042734	presynaptic membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0015085	calcium ion transmembrane transporter activity
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0005388	P-type calcium transporter activity
Molecular Function	GO:1905056	P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration
Biological Process	GO:1990034	calcium ion export across plasma membrane
Biological Process	GO:0034220	monoatomic ion transmembrane transport
Biological Process	GO:1903779	regulation of cardiac conduction
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration

Reference

[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.