Search Results
Overview
| Uniprot ID | Q16775 |
|---|---|
| Protein Name | Hydroxyacylglutathione hydrolase, mitochondrial |
| Gene Name | HAGH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | DHAGGNEKLVKLESG |
| 116 | GGNEKLVKLESGLKV |
| 136 | RIGALTHKITHLSTL |
| 229 | EYTINNLKFARHVEP |
| 249 | REKLAWAKEKYSIGE |
| 278 | PFMRVREKTVQQHAG |
| 304 | RREKDQFKMPRD*** |
Function
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid
Protein Sequence
10
MVVGRGLLGR
20
RSLAALGAAC
30
ARRGLGPALL
40
GVFCHTDLRK
50
NLTVDEGTMK
60
VEVLPALTDN
70
YMYLVIDDET
80
KEAAIVDPVQ
90
PQKVVDAARK
100
HGVKLTTVLT
110
THHHWDHAGG
120
NEKLVKLESG
130
LKVYGGDDRI
140
GALTHKITHL
150
STLQVGSLNV
160
KCLATPCHTS
170
GHICYFVSKP
180
GGSEPPAVFT
190
GDTLFVAGCG
200
KFYEGTADEM
210
CKALLEVLGR
220
LPPDTRVYCG
230
HEYTINNLKF
240
ARHVEPGNAA
250
IREKLAWAKE
260
KYSIGEPTVP
270
STLAEEFTYN
280
PFMRVREKTV
290
QQHAGETDPV
300
TTMRAVRREK
DQFKMPRD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004416 | hydroxyacylglutathione hydrolase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006750 | glutathione biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.