Search Results

Overview

Uniprot ID	Q16795
Protein Name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Gene Name	NDUFA9
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
175	SHLNANIKSSSRYLR
184	SSRYLRNKAVGEKVV
373	IEDVKPAKTVNI***

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Required for proper complex I assembly (PubMed:28671271). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Protein Sequence

10 MAAAAQSRVV 20 RVLSMSRSAI 30 TAIATSVCHG 40 PPCRQLHHAL 50 MPHGKGGRSS 60 VSGIVATVFG 70 ATGFLGRYVV 80 NHLGRMGSQV 90 IIPYRCDKYD 100 IMHLRPMGDL 110 GQLLFLEWDA 120 RDKDSIRRVV 130 QHSNVVINLI 140 GRDWETKNFD 150 FEDVFVKIPQ 160 AIAQLSKEAG 170 VEKFIHVSHL 180 NANIKSSSRY 190 LRNKAVGEKV 200 VRDAFPEAII 210 VKPSDIFGRE 220 DRFLNSFASM 230 HRFGPIPLGS 240 LGWKTVKQPV 250 YVVDVSKGIV 260 NAVKDPDANG 270 KSFAFVGPSR 280 YLLFHLVKYI 290 FAVAHRLFLP 300 FPLPLFAYRW 310 VARVFEISPF 320 EPWITRDKVE 330 RMHITDMKLP 340 HLPGLEDLGI 350 QATPLELKAI 360 EVLRRHRTYR 370 WLSAEIEDVK PAKTVNI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0031966	mitochondrial membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0045271	respiratory chain complex I
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity
Molecular Function	GO:0003954	NADH dehydrogenase activity
Molecular Function	GO:0044877	protein-containing complex binding
Biological Process	GO:0009060	aerobic respiration
Biological Process	GO:0007623	circadian rhythm
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis
Biological Process	GO:0006814	sodium ion transport
Biological Process	GO:0006744	ubiquinone biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.