Search Results
Overview
| Uniprot ID | Q16799 |
|---|---|
| Protein Name | Reticulon-1 |
| Gene Name | RTN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 248 | KPAPVEGKIIKDHLL |
| 251 | PVEGKIIKDHLLEES |
| 364 | ITAIKEAKGLSYETA |
| 767 | VVAKIQAKIPGAKRH |
Function
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity
Protein Sequence
10
MAAPGDPQDE
20
LLPLAGPGSQ
30
WLRHRGEGEN
40
EAVTPKGATP
50
APQAGEPSPG
60
LGARAREAAS
70
REAGSGPARQ
80
SPVAMETAST
90
GVAGVSSAMD
100
HTFSTTSKDG
110
EGSCYTSLIS
120
DICYPPQEDS
130
TYFTGILQKE
140
NGHVTISESP
150
EELGTPGPSL
160
PDVPGIESRG
170
LFSSDSGIEM
180
TPAESTEVNK
190
ILADPLDQMK
200
AEAYKYIDIT
210
RPEEVKHQEQ
220
HHPELEDKDL
230
DFKNKDTDIS
240
IKPEGVREPD
250
KPAPVEGKII
260
KDHLLEESTF
270
APYIDDLSEE
280
QRRAPQITTP
290
VKITLTEIEP
300
SVETTTQEKT
310
PEKQDICLKP
320
SPDTVPTVTV
330
SEPEDDSPGS
340
ITPPSSGTEP
350
SAAESQGKGS
360
ISEDELITAI
370
KEAKGLSYET
380
AENPRPVGQL
390
ADRPEVKARS
400
GPPTIPSPLD
410
HEASSAESGD
420
SEIELVSEDP
430
MAAEDALPSG
440
YVSFGHVGGP
450
PPSPASPSIQ
460
YSILREEREA
470
ELDSELIIES
480
CDASSASEES
490
PKREQDSPPM
500
KPSALDAIRE
510
ETGVRAEERA
520
PSRRGLAEPG
530
SFLDYPSTEP
540
QPGPELPPGD
550
GALEPETPML
560
PRKPEEDSSS
570
NQSPAATKGP
580
GPLGPGAPPP
590
LLFLNKQKAI
600
DLLYWRDIKQ
610
TGIVFGSFLL
620
LLFSLTQFSV
630
VSVVAYLALA
640
ALSATISFRI
650
YKSVLQAVQK
660
TDEGHPFKAY
670
LELEITLSQE
680
QIQKYTDCLQ
690
FYVNSTLKEL
700
RRLFLVQDLV
710
DSLKFAVLMW
720
LLTYVGALFN
730
GLTLLLMAVV
740
SMFTLPVVYV
750
KHQAQIDQYL
760
GLVRTHINAV
770
VAKIQAKIPG
AKRHAE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0014069 | postsynaptic density |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0071787 | endoplasmic reticulum tubular network formation |
| Biological Process | GO:1990809 | endoplasmic reticulum tubular network membrane organization |
| Biological Process | GO:1902430 | negative regulation of amyloid-beta formation |
| Biological Process | GO:0030182 | neuron differentiation |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.